{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:25:08Z","timestamp":1787851508898,"version":"build-2784847793"},"reference-count":69,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2023-00227274"],"award-info":[{"award-number":["RS-2023-00227274"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medicinal Food"],"abstract":"<jats:p>\n                    Metabolic dysfunction-associated steatotic liver disease (MASLD) develops through systemic metabolic dysregulation and gut\u2013liver axis-mediated inflammation; however, effective preventive strategies remain limited. Probiotics such as\n                    <jats:italic toggle=\"yes\">Lactiplantibacillus plantarum<\/jats:italic>\n                    have emerged as potential modulators of intestinal barrier integrity and hepatic inflammation; however, preventive efficacy during early MASLD progression has not been fully elucidated. The present study evaluated whether\n                    <jats:italic toggle=\"yes\">L. plantarum<\/jats:italic>\n                    Q180 attenuates early high-fat diet (HFD)-induced MASLD in a murine model. Male C57BL\/6J mice were fed a normal diet or 60% HFD for 12 weeks, and Q180 was orally administered at 1.0 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    CFU\/day from weeks 5 to 12. HFD feeding induced obesity, hepatic lipid accumulation, and an elevated nonalcoholic fatty liver disease activity score (NAS), confirming early-stage MASLD. Although Q180 did not significantly reduce body weight gain or adipose tissue mass, Q180 did significantly decrease hepatic triglyceride levels and NAS, accompanied by improvements in steatosis, hepatocellular ballooning, and inflammatory infiltration. Hepatic expressions of\n                    <jats:italic toggle=\"yes\">Dgat1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Sod<\/jats:italic>\n                    were significantly upregulated, whereas\n                    <jats:italic toggle=\"yes\">Ldlr<\/jats:italic>\n                    expression was downregulated. In the colon, Q180 markedly suppressed\n                    <jats:italic toggle=\"yes\">Tnf-\u03b1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Il-6<\/jats:italic>\n                    expression and partially restored\n                    <jats:italic toggle=\"yes\">Zo-1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Occludin<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Muc2<\/jats:italic>\n                    expressions. Serum endotoxin levels were significantly reduced, and a decreasing trend was observed in fecal endotoxin levels. Overall, Q180 exerted metabolic and immunological benefits during early MASLD progression by reducing hepatic lipid accumulation, enhancing antioxidant defenses, attenuating intestinal inflammation, reinforcing intestinal barrier integrity, and lowering endotoxin exposure. The results support Q180 as a promising probiotic candidate for the prevention and early management of MASLD through gut\u2013liver axis modulation.\n                  <\/jats:p>","DOI":"10.1177\/1096620x261481601","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:17:57Z","timestamp":1787656677000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Lactiplantibacillus plantarum<\/i>\n                    Q180 Mitigates Early High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Gut\u2013Liver Axis Inflammation and Barrier Integrity"],"prefix":"10.1177","author":[{"given":"Yeon-Woo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunchae","family":"Joung","sequence":"additional","affiliation":[{"name":"Microbiome Research Laboratory, Chong Kun Dang Bio (CKDBiO) Research Institute, Ansan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Microbiome Research Laboratory, Chong Kun Dang Bio (CKDBiO) Research Institute, Ansan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-7124","authenticated-orcid":false,"given":"Chang Hun","family":"Shin","sequence":"additional","affiliation":[{"name":"Chong Kun Dang Bio Research Institute, Ansan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-531X","authenticated-orcid":false,"given":"Jung-Heun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000539371"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1433857"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101127"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104714"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110539"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2304157"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-331003"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01119-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70139"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goae029"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.2196\/46891"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI186420"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332398"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-01003-6"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl240539"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1618275"},{"issue":"4","key":"e_1_3_2_18_1","first-page":"763","article-title":"Akkermansia muciniphila and Bifidobacterium bifidum prevent NAFLD by regulating FXR expression and gut microbiota","volume":"11","author":"Nian F","year":"2023","unstructured":"17.Nian F, , Wu L, , Xia Q, et al. 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Lactiplantibacillus plantarum Q180 (CKD BiO Recognition No. 2021-23). Food Safety Korea Available from: https:\/\/www.foodsafetykorea.go.kr\/portal\/board\/boardDetail.do?menu_grp=MENU_NEW01&menu_no=2660&bbs_no=bbs987&nticmatr_yn=N&bbs_type_cd=01&ans_yn=N&ntctxt_no=1088683 [Last accessed: May17 2026]."},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1213"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2024.29.3.270"}],"container-title":["Journal of Medicinal Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261481601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1096620X261481601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1096620X261481601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:50:41Z","timestamp":1787849441000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1096620X261481601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":69,"alternative-id":["10.1177\/1096620X261481601"],"URL":"https:\/\/doi.org\/10.1177\/1096620x261481601","relation":{},"ISSN":["1096-620X","1557-7600"],"issn-type":[{"value":"1096-620X","type":"print"},{"value":"1557-7600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"article-number":"1096620X261481601"}}