{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:53:07Z","timestamp":1777935187333,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100024212","name":"Japanese Society for Palliative Medicine","doi-asserted-by":"crossref","award":["Research Advancement on Palliative Medicine (grant"],"award-info":[{"award-number":["Research Advancement on Palliative Medicine (grant"]}],"id":[{"id":"10.13039\/100024212","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dyspnea is common in advanced cancer, especially with unilateral pleural effusion. Lateral positioning is widely used, but evidence of effectiveness is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the feasibility and short-term effects of affected-side-down (PLEUR-DOWN) versus affected-side-up (PLEUR-UP) positioning for dyspnea relief.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicenter randomized crossover pilot trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>Ten patients with cancer with dyspnea were enrolled at seven hospitals in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients (numerical rating scale [NRS] \u2265 3) were randomized to two sequences. Each position was maintained for five minutes within a washout period. The primary outcome was feasibility, assessed by completion, absence of carryover\/period effects, and adherence. Secondary outcomes included NRS changes, patient preference, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients completed the trial. No significant carryover (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.57) or period effects (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.25) were found. Mean NRS difference favored PLEUR-DOWN (\u22120.9;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.34). Half preferred PLEUR-DOWN. No adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The trial confirmed feasibility and supports further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10966218251377535","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:20:41Z","timestamp":1758039641000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Body Positioning for Dyspnea in Patients with Cancer with Unilateral Pleural Effusion: A Pilot Trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-6275","authenticated-orcid":false,"given":"Jun","family":"Kako","sequence":"first","affiliation":[{"name":"Graduate School of Medicine, Mie University, Tsu, 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