{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T10:59:28Z","timestamp":1780829968641,"version":"3.54.1"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"abstract":"\n Background:<\/jats:title>\n Opioid-induced constipation (OIC) limits opioid titration in cancer care. Before the use of peripherally acting \u03bc-opioid receptor antagonists (PAMORAs), OIC often required switching from oxycodone to lower-risk opioids, such as transdermal fentanyl. Whether naldemedine allows oxycodone escalation without switching remains unclear. We evaluated the maximum scheduled daily oxycodone dose as a surrogate for maintaining therapy without constipation-driven switching.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We retrospectively reviewed adults with cancer pain who initiated oral oxycodone at Toyama University Hospital between June 2017 and December 2018. Patients receiving naldemedine were classified as Group A; others as Group B. The primary endpoint was the maximum scheduled controlled-release oxycodone dose during follow-up; rescue doses were excluded.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among 217 patients, the median maximum dose was higher with naldemedine (40 mg\/day [range 10\u2013480] versus 20 mg\/day [10\u2013320];\n p<\/jats:italic>\n < 0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Naldemedine enabled higher oxycodone dosing, suggesting OIC management reduces opioid switching.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10966218251415472","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:15:33Z","timestamp":1771337733000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Naldemedine Allow Higher Oxycodone Dosing in Patients with Cancer? A Single-Center Retrospective Study"],"prefix":"10.1177","author":[{"given":"Shinya","family":"Kajiura","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Palliative Medicine, Toyama University Hospital, Toyama, Japan."},{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."},{"name":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Chikaoka","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Yagi","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Ryu","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Kanai","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Palliative Medicine, Toyama University Hospital, Toyama, Japan."},{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutatsu","family":"Yuki","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Nagata","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iori","family":"Motoo","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ando","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Palliative Medicine, Toyama University Hospital, Toyama, Japan."},{"name":"Palliative Care Team, Toyama University Hospital, Toyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12398"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00495.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2012.28792"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.0853"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00381"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102704"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy12020048"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14496"}],"container-title":["Journal of Palliative 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