{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:53:41Z","timestamp":1777935221422,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"abstract":"<jats:p>Seizures are common at the end of life. Seizures can be especially distressing if they are refractory to conventional antiepileptic treatments. We present the histories of two terminally ill patients with refractory status epilepticus who did not respond to standard antiepileptic protocols. Seizure control was eventually achieved with the use of parenteral ketamine infusion dosed at 1 mg\/kg\/hour. Parenteral ketamine infusion is not traditionally used in palliative care for seizure management. However, our experience shows there is promise that it can be a viable option for refractory status epilepticus. For one of the patients, ketamine was initiated in the general ward setting. This highlights that seizure control can be achieved without a transfer to intensive care as such a transfer may not be consistent with a dying patient\u2019s goals of care. Further studies should be conducted in palliative care settings to evaluate the use of ketamine for terminal refractory status epilepticus.<\/jats:p>","DOI":"10.1177\/10966218261426895","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:56:22Z","timestamp":1773320182000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketamine Infusion for Refractory Status Epilepticus\u2014A Tale of Two Patients"],"prefix":"10.1177","author":[{"given":"Sherryl Lei","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Kaiwei","family":"Wei Tan","sequence":"additional","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen Ying","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella Seow Lin","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4174-7619","authenticated-orcid":false,"given":"Shirlyn Hui-Shan","family":"Neo","sequence":"additional","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."},{"name":"Lien Centre for Palliative Care, Duke-NUS Medical School, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vengadasalam","family":"Murugam","sequence":"additional","affiliation":[{"name":"Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npu018"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-022-04133-1"},{"key":"e_1_3_2_4_1","unstructured":"3.FF #229 Seizure Management in the Dying Patient. 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