{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:03:17Z","timestamp":1784620997082,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the University of Tsukuba"},{"name":"the University of Tsukuba","award":["Grant for Implementation of Advanced Medicine (GIA"],"award-info":[{"award-number":["Grant for Implementation of Advanced Medicine (GIA"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Clinical guidelines recommend naldemedine for opioid-induced constipation in patients with cancer, either with conventional laxatives or as a first-choice option. Making prophylactic naldemedine a new standard treatment for opioid-induced constipation requires a demonstration of its value for money.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to evaluate the cost-effectiveness of prophylactic naldemedine in patients with cancer initiating strong opioid therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We conducted a cost-effectiveness analysis of prophylactic naldemedine replacing standard, nonprophylactic use from the payer\u2019s perspective, using a decision tree model based on data from a multicenter, double-blind, randomized controlled trial in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>The study population included patients aged \u226520 years and initiating strong opioid therapy for the first time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incremental cost-effectiveness ratio of prophylactic naldemedine for opioid-induced constipation was 1,445,276 Japanese yen (\u00a5) or 9,635 United States dollars (USD) with an exchange rate of 1 USD = 150 \u00a5 per quality-adjusted life year. Using the official value of social willingness-to-pay threshold in Japan of 5 million \u00a5 or 33,333 USD per quality-adjusted life year gained, prophylactic naldemedine was found to be cost-effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first global cost-effectiveness analysis of prophylactic naldemedine in patients with cancer. Prophylactic naldemedine for opioid-induced constipation in patients with cancer initiating strong opioid therapy could be justifiable as an efficient use of finite health care resources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10966218261440391","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:49:32Z","timestamp":1775872172000},"page":"904-911","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-Effectiveness of Prophylactic Naldemedine for Opioid-Induced Constipation in Patients with Cancer"],"prefix":"10.1177","volume":"29","author":[{"given":"Reiko","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Health Care Policy and Health Economics, Institute of Medicine, University of Tsukuba, Tsukuba, Japan."},{"name":"Department of Clinical Laboratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Higashibata","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-4375","authenticated-orcid":false,"given":"Masahide","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Health Care Policy and Health Economics, Institute of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita, Japan."},{"name":"Department of Gastroenterology, International University Health and Welfare Graduate School of Medicine, Narita, Japan."},{"name":"Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2341"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy148"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.016"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05016-4"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.12.010"},{"key":"e_1_3_3_7_1","volume-title":"Clinical Guidelines for Cancer Pain Management","author":"The Japanese Society for Palliative Medicine","year":"2014","unstructured":"6.The Japanese Society for Palliative Medicine. Clinical Guidelines for Cancer Pain Management. 3rd ed. KANEHARA & Co., Ltd: Tokyo; 2014.","edition":"3"},{"key":"e_1_3_3_8_1","volume-title":"Evidence-Based Clinical Practice Guidelines for Chronic Constipation 2023 (in Japanese)","author":"The Japanese Gastroenterological Association","year":"2023","unstructured":"7.The Japanese Gastroenterological Association. Evidence-Based Clinical Practice Guidelines for Chronic Constipation 2023 (in Japanese). 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Available from: https:\/\/www.mhlw.go.jp\/topics\/2024\/04\/tp20240401-01.html [Last accessed: April1 2025]."},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3015(10)66617-X"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696990903584436"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04244.x"},{"key":"e_1_3_3_28_1","unstructured":"27.National Institute for Health and Care Excellence. Naldemedine for treating opioid-induced constipation. Technology appraisal guidance. TA651. 2020. 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