{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T18:25:09Z","timestamp":1786904709841,"version":"build-2736575974"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"abstract":"\n Objective:<\/jats:title>\n To investigate the use, feasibility and tolerability of bolus subcutaneous injection of pantoprazole in the specialist palliative care hospice inpatient setting.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n A retrospective review of the electronic records and paper administration charts of the first 10 patients who received a slow bolus subcutaneous injection of pantoprazole in a hospice inpatient unit.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The most common indications for a proton pump inhibitor were gastro-esophageal reflux disease and gastroprotection. Loss of swallow in the last days of life was the most common reason for the subcutaneous route. 80% of patients tolerated bolus subcutaneous pantoprazole and may have received clinical benefit. Two patients developed skin irritation at the subcutaneous injection site.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Bolus subcutaneous pantoprazole is a potential alternative treatment when a proton pump inhibitor is indicated, and the oral route is not available or effective. There is a risk of skin irritation requiring careful monitoring. Controlled research is needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10966218261478681","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:29:32Z","timestamp":1786685372000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Survey of the Use of Bolus Subcutaneous Injection of Pantoprazole in Palliative Care"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0133-8015","authenticated-orcid":false,"given":"Eloise","family":"Naylor","sequence":"first","affiliation":[{"name":"John Eastwood Hospice, Nottinghamshire Healthcare NHS Foundation Trust, Sutton-in-Ashfield, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpna","family":"Chauhan","sequence":"additional","affiliation":[{"name":"John Eastwood Hospice, Nottinghamshire Healthcare NHS Foundation Trust, Sutton-in-Ashfield, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.Wilcock A Howard P Stark Toller C et al. Palliative care formulary. Pharmaceutical Press: London; 2026. Available from: http:\/\/www.medicinescomplete.com\/ [Last accessed: March9 2026]."},{"key":"e_1_3_3_3_1","volume-title":"StatPearls","author":"Ahmed A","year":"2026","unstructured":"2.Ahmed A, , Clarke JO. Proton Pump Inhibitors (PPI). In: StatPearls. StatPearls Publishing: Treasure Island, FL; 2026. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557385\/"},{"key":"e_1_3_3_4_1","unstructured":"3.NICE. Prescribing in palliative care. Available from: https:\/\/bnf.nice.org.uk\/medicines-guidance\/prescribing-in-palliative-care\/ [Last accessed: March9 2026]."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2019-001916"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.05.029"},{"key":"e_1_3_3_7_1","unstructured":"6.Medusa. Pantoprazole\u2014IntraVENOUS adult monograph. Available from: https:\/\/imgmedusa.nhs.uk\/auth\/login [Last accessed: July2 2026]."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.10.005"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02420.x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13582"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/spcare-2025-005561"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2021-003510"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/spcare-2023-004593"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10966218261478681","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10966218261478681","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10966218261478681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T17:49:51Z","timestamp":1786902591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10966218261478681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":12,"alternative-id":["10.1177\/10966218261478681"],"URL":"https:\/\/doi.org\/10.1177\/10966218261478681","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"article-number":"10966218261478681"}}