{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:36:57Z","timestamp":1792867017510,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The wish to hasten death (WTHD) is a recognized expression of suffering in advanced illness, yet remains systematically underexplored in Latin America, where data are virtually absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the prevalence of the WTHD, and identify associated factors and predictors in advanced cancer patients receiving palliative care in Argentina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional descriptive study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>One hundred consecutive patients with stage IV cancer under active palliative care follow-up at a university hospital in Argentina were enrolled between January 2024 and December 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>WTHD was assessed using the AFEDD interview; it was identified in 35% of patients based on a positive screening response with severity scores among these patients ranging from 2 to 7 (median = 5). Symptom burden was measured with the revised Edmonton Symptom Assessment System (ESAS-r); total scores were calculated both with and without the additional item \u201cfeeling like a burden to others.\u201d Demoralization was assessed using the Demoralization Scale-II (DS-II), with a cutoff score of \u226510.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      WTHD was identified in 35% of patients that scored between 2 and 7 (median = 5). Among those, most scored at the lower end of the clinical continuum (\u2976\n                      <jats:italic toggle=\"yes\">x<\/jats:italic>\n                      ), without active planning. Patients who scored high in WTHD (\u2978\n                      <jats:italic toggle=\"yes\">x<\/jats:italic>\n                      ) showed significantly higher symptom burden (median ESAS-r 41.0 vs. 31.0;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and demoralization rates (62.9% vs. 23.1%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). In multivariate logistic regression, demoralization was the only independent predictor of WTHD (OR = 6.56; 95% CI: 2.47\u201318.53;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Demoralization is the key factor associated with the WTHD in this Latin American palliative care sample. Proactive, multidimensional assessment addressing meaning, dignity, and relational suffering is essential for comprehensive end-of-life care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10966218261500244","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:17:37Z","timestamp":1792721857000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Wish to Hasten Death in Advanced Cancer Patients Receiving Palliative Care. A Cross-Sectional Study in a Latin American Setting"],"prefix":"10.1177","author":[{"given":"Mar\u00eda del Pilar","family":"Mendiguren","sequence":"first","affiliation":[{"name":"Unidad de Cuidados Paliativos, Hospital Universitario Austral (HUA), Pilar, Argentina."},{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-5054","authenticated-orcid":false,"given":"Agustina","family":"Iturri","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Paliativos, Hospital Universitario Austral (HUA), Pilar, Argentina."},{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Pilar","family":"De Antueno","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Paliativos, Hospital Universitario Austral (HUA), Pilar, Argentina."},{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Najun","sequence":"additional","affiliation":[{"name":"Unidad de Cuidados Paliativos, Hospital Universitario Austral (HUA), Pilar, Argentina."},{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5252-4056","authenticated-orcid":false,"given":"Maria","family":"Maluenda Martinez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Gunning","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Macias","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lujan","family":"Rufino","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Urdaiz","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Andrea","family":"Alc\u00e1ntar Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna Beatriz","family":"Quiroga Candela","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfina","family":"Magneres","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas (FCB), Universidad Austral, Pilar, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Monforte-Royo","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146184"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2024.04.023"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037117"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016659"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-024-01018-y"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medipa.2016.09.002"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002234"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/02692163241269689"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2017.04.018"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4900"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.18270\/rce.v18i1.2341"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bioe.12562"},{"key":"e_1_3_4_14_1","first-page":"e202110138","article-title":"[Wish to hasten death in home palliative care. Look for your seven percent.]","volume":"95","author":"Busquet-Duran X","year":"2021","unstructured":"13.Busquet-Duran X, , Jim\u00e9nez-Zafra EM, , Mart\u00ednez-Losada EJ, et al. [Wish to hasten death in home palliative care. Look for your seven percent.]. 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