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Immunohistochemical expression of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) was assessed in the tumours of seven cats. Tumour location varied greatly. The cats had a mean age of 13 years. Three cats had a previous diagnosis of feline idiopathic cystitis of up to 2008 days duration. Ten of the cats showed clinical improvement (reduction of haematuria and\/or dysuria), with a mean survival time (MST) of 311 days (range 10\u20131064); 1-year survival of 50%. All seven bladders assessed for COX staining were COX-1 positive and five were COX-2 positive. The MST for the COX-2-positive cats was 123 days, the MST for the COX-2-negative cases was 375 days.<\/jats:p>","DOI":"10.1177\/1098612x12442041","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T23:37:41Z","timestamp":1331336261000},"page":"527-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam"],"prefix":"10.1177","volume":"14","author":[{"given":"Nicholas X","family":"Bommer","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, The University of Edinburgh, Roslin, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M","family":"Hayes","sequence":"additional","affiliation":[{"name":"Longacre, Ely, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Scase","sequence":"additional","affiliation":[{"name":"Bridge Pathology Ltd, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8lle A","family":"Gunn-Moore","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, The University of Edinburgh, Roslin, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00032-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1986.tb03961.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02424.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.1.101"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287398909531360"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-1439(99)00006-X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113186"},{"key":"e_1_3_3_9_2","first-page":"733","article-title":"Transitional cell carcinoma of the bladder associated with cyclophosphamide therapy in a dog","volume":"5","author":"Weller RE","year":"1979","unstructured":"Weller RE, Wold AM, Dyjido A. 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