{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:45:38Z","timestamp":1792575938449,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    A retrospective study assessing treatment-related toxicities in tumor-bearing cats treated with temozolomide (TMZ) alone or in combination with doxorubicin was conducted. TMZ was administered orally once a day for 5 days every 3 weeks at a dose of 20 mg\/cat. Tumor response was evaluated with standard World Health Organization criteria and toxicity was monitored using veterinary co-operative oncology group\u2013common terminology criteria for adverse events (VCOG\u2014CTCAE) criteria. Ten tumor-bearing cats with various types of malignancies were treated with TMZ-based chemotherapy. Eight cats were evaluable for response. Two cats achieved a complete response, one achieved stable disease and five achieved a partial response. Four grade III and one grade IV hematological toxicities, and one grade IV gastrointestinal toxicity were observed. Four cats were euthanased as a result of apparent toxicity. One cat was euthanased as a result of severe and prolonged myelosuppression with fever. Three were euthanased for grade III pleural and pericardial effusions. Effusion was seen in cats treated with higher cumulative dose of TMZ (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.0046). Planned additional case accrual was discontinued because of unacceptable levels of toxicity despite evidence of efficacy in some of the cats. Additional investigation is needed to elucidate this unexpected apparent cumulative toxicity.\n                  <\/jats:p>","DOI":"10.1177\/1098612x12445146","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T20:37:31Z","timestamp":1334176651000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment-related toxicities in tumor-bearing cats treated with temozolomide alone or in combination with doxorubicin: a pilot assessment"],"prefix":"10.1177","volume":"14","author":[{"given":"Jerome","family":"Gagnon","sequence":"first","affiliation":[{"name":"VCA Berwyn Animal Hospital, Berwyn, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G","family":"Dervisis","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E","family":"Kitchell","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1987.tb01983.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01024.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.12.009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1977.171.08.692a"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1977.171.03.277"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03225.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.3.510"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb01166.x"},{"key":"e_1_3_2_10_2","first-page":"310","volume-title":"Cancer chemotherapy and biotherapy: principles and practice","author":"Friedman HS","year":"2006","unstructured":"Friedman HS, Kurtzberg J, Averbuch SD. 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Philadelphia, PA: Lippincott Williams & Wilkins, 2008, pp407\u2013419.","edition":"8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0376.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1990.tb00896.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.4.563"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.0005.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3727\/0965040041292341"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.0053b.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb02311.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5326\/0380357"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-072160558-6.50014-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-5-416"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02085.x"},{"key":"e_1_3_2_23_2","first-page":"1093","article-title":"Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer","volume":"3","author":"Dhodapkar M","year":"1997","unstructured":"Dhodapkar M, Rubin J, Reid JM, Burch PA, Pitot HC, Buckner JC, et al. Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer. 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