{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:45:07Z","timestamp":1788317107124,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>The study describes the pharmacokinetics and predicted efficacy of imipenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to five adult cats at a dose of 5 mg\/kg. Susceptibility to imipenem [minimum inhibitory concentration (MIC)] was determined for antimicrobial resistant Escherichia coli (n = 13) and staphylococci (n = 3) isolated from domestic cat infections (urinary system, skin and conjunctiva). Maximum plasma concentrations of imipenem were 13.45 \u00b5g\/ml (IV), 6.47 \u00b5g\/ml (IM) and 3.83 \u00b5g\/ml (SC). Bioavailability was 93.18% (IM) and 107.90% (SC). Elimination half-lives for IV, IM and SC administration were 1.17, 1.44 and 1.55 h, respectively. All tested bacteria were susceptible to imipenem; MIC values were 0.03 \u00b5g\/ml for Staphylococcus species and &lt;0.25\u20130.5 \u00b5g\/ml for E coli. Mean imipenem concentrations remained above a MIC of 0.5 \u00b5g\/ml for approximately 4 h (IV and IM) and 9 h (SC). Imipenem would be predicted to be effective for the treatment of antimicrobial resistant bacterial infections in cats at a dosage of 5 mg\/kg every 6\u20138 h (IV, IM), or longer for the SC route. However, clinical trials are mandatory to establish its efficacy and proper dosing.<\/jats:p>","DOI":"10.1177\/1098612x12471526","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T05:12:57Z","timestamp":1355980377000},"page":"483-487","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetics of imipenem after intravenous, intramuscular and subcutaneous administration to cats"],"prefix":"10.1177","volume":"15","author":[{"given":"Gabriela A","family":"Albarellos","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Veterinary Science, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela A","family":"Denamiel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Veterinary Science, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Montoya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Veterinary Science, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C","family":"Quaine","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Veterinary Science, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn P","family":"Lupi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Veterinary Science, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F","family":"Landoni","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Veterinary Science, University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,19]]},"reference":[{"key":"bibr1-1098612X12471526","first-page":"159","volume-title":"Antimicrobial therapy in veterinary medicine","author":"Prescott JF","year":"2006","edition":"4"},{"key":"bibr2-1098612X12471526","unstructured":"CLSI Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard. 3rd ed. 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