{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:38:52Z","timestamp":1792579132202,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    In order to describe the signs of acromegaly in cats, a case-control study was done based on computed tomography (CT) scans of the heads of 68 cats with hypersomatotropism and 36 control cats. All cats with a diagnosis of hypersomatotropism had diabetes mellitus, serum insulin-like growth factor-1 &gt;1000 ng\/ml and a pituitary mass. Measurements of bones and soft tissues were done by two independent observers without knowledge of the diagnosis. Pituitary masses were identified in CT images of 64 (94%) cats with hypersomatotropism. Analysis of variance found a moderate effect of gender on the size of bones and a large effect of hypersomatotropism on the size of bones and thickness of soft tissues. In cats with hypersomatotropism the frontal and parietal bones were, on average, 0.8 mm thicker (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001); the distance between the zygomatic arches was, on average, 5.4 mm greater (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001); and the mandibular rami were, on average, 1.1 mm thicker (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001) than in control cats. The skin and subcutis dorsal to the frontal bone were, on average, 0.4 mm thicker (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001); lateral to the zygomatic arch were, on average, 0.7 mm thicker (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001); and ventral to the mandibular rami were, on average, 1.1 mm thicker (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.002) in cats with hypersomatotropism than in control cats. The cross-sectional area of the nasopharynx was, on average, 11.1 mm\n                    <jats:sup>2<\/jats:sup>\n                    smaller in cats with hypersomatotropism than in control cats (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02). Prognathia inferior and signs of temporomandibular joint malformation were both observed more frequently in cats with hypersomatotropism than in control cats (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.03). Overall, differences between affected and unaffected cats were small. Recognising feline acromegaly on the basis of facial features is difficult.\n                  <\/jats:p>","DOI":"10.1177\/1098612x13497212","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T23:45:53Z","timestamp":1373586353000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Computed tomographic signs of acromegaly in 68 diabetic cats with hypersomatotropism"],"prefix":"10.1177","volume":"16","author":[{"given":"Christopher R","family":"Lamb","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00edzha C","family":"Ciasca","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Mantis","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Forcada","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maegan","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn J","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, North Mymms, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra062453"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03626.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510439"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1990.tb00897.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03041.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03039.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.12.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03040.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1765"},{"key":"e_1_3_3_11_2","first-page":"152","article-title":"Acromegaly diagnosed by increased IGF-1 levels and MRI findings in two cats","volume":"39","author":"Meffert FJ","year":"2009","unstructured":"Meffert FJ, Brown JS. Acromegaly diagnosed by increased IGF-1 levels and MRI findings in two cats. Austr Vet Pract 2009; 39: 152\u2013155.","journal-title":"Austr Vet Pract"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01821.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01957.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00214.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00006.x"},{"key":"e_1_3_3_16_2","first-page":"334","article-title":"Morphological characteristics of the paranasal sinuses in brachycephalic cats and their functional relevance","volume":"89","author":"Kunzel W","year":"2002","unstructured":"Kunzel W, Breit S, Oppel M. Morphological characteristics of the paranasal sinuses in brachycephalic cats and their functional relevance. Wien Tier\u00e4rztl Monatsschr 2002; 89: 334\u2013340.","journal-title":"Wien Tier\u00e4rztl Monatsschr"},{"key":"e_1_3_3_17_2","first-page":"213","article-title":"Topography and imaging methods (x-rays and computertomography) on the paranasal sinuses of the cat","volume":"47","author":"Koch R","year":"2002","unstructured":"Koch R, Schroder H, Waibl H. Topography and imaging methods (x-rays and computertomography) on the paranasal sinuses of the cat. Kleintierpraxis 2002; 47: 213\u2013219.","journal-title":"Kleintierpraxis"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X13497212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X13497212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X13497212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:46:46Z","timestamp":1792576006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X13497212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,11]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1177\/1098612X13497212"],"URL":"https:\/\/doi.org\/10.1177\/1098612x13497212","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,11]]}}}