{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:38:46Z","timestamp":1792579126213,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    The objective of this prospective, multicentre, non-controlled, open-label study was to evaluate the effects of an iodine-restricted food on circulating total thyroxine (TT4) concentrations and clinical parameters in client-owned cats with hyperthyroidism. Two hundred and twenty-five cats were enrolled in the study and adapted to the iodine-restricted food. Data from physical examinations, questionnaires completed by veterinarians and owners, and circulating concentrations of TT4, urea and creatinine were recorded at weeks 0, 4 and 8. The study group included 136 female and 89 male cats (median age 15 years, range 4\u201321 years). Group 1 (n = 113) had been on previous anti-thyroid medication, while group 2 (n = 112) consisted of newly diagnosed cats. No differences were found between the two groups at any time point. Circulating TT4 concentrations had decreased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.0001) at week 4 and did not change significantly from week 4 to week 8. Circulating TT4 concentration was within the reference range in 56\/88 cats at week 4 and in 51\/68 cats at week 8. Clinical parameters (vomiting, polyuria, polydipsia, hyperactivity, polyphagia, weight loss, hair coat quality, and quality of life) had improved (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.0001) by week 4. Circulating creatinine concentration decreased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001) from week 0 to week 4. Side effects associated with feeding the iodine-restricted food were not observed. In conclusion, in client-owned cats with hyperthyroidism an iodine-restricted food is a valuable management option to normalise circulating TT4 concentrations, and improve clinical signs of hyperthyroidism within 4 weeks. This applies to newly diagnosed cats, as well as to previously diagnosed cats receiving anti-thyroid drugs.\n                  <\/jats:p>","DOI":"10.1177\/1098612x13512627","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T22:33:10Z","timestamp":1384468390000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of an iodine-restricted food on client-owned cats with hyperthyroidism"],"prefix":"10.1177","volume":"16","author":[{"given":"Marieke","family":"van der Kooij","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Utrecht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Be\u010dv\u00e1\u0159ov\u00e1","sequence":"additional","affiliation":[{"name":"Hill\u2019s Pet Nutrition, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein P","family":"Meyer","sequence":"additional","affiliation":[{"name":"Hill\u2019s Pet Nutrition, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Teske","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Utrecht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans S","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Utrecht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1980.176.04.345"},{"key":"e_1_3_3_3_2","first-page":"108","volume-title":"ACVIM conference, Seattle","author":"Peterson ME","unstructured":"Peterson ME, Johnson GF, Andrews LK. 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