{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:38:28Z","timestamp":1792579108152,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    The incidence of cefotaximase (CTX-M)-type extended-spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    has increased dramatically in humans and animals since the middle of the last century.\n                    <jats:italic toggle=\"yes\">E coli<\/jats:italic>\n                    that produce CTX-M \u03b2-lactamase represent a major cause of urinary tract infections, and pose a significant therapeutic challenge to both human and veterinary medicine. As data on uropathogenic CTX-M-producing strains in cats are limited, the aim of this study was to describe the genetic character and antibiotic resistance phenotypes of CTX-M-producing\n                    <jats:italic toggle=\"yes\">E coli<\/jats:italic>\n                    isolated from cats with cystitis. Seven of 15\n                    <jats:italic toggle=\"yes\">E coli<\/jats:italic>\n                    bacteria isolated from 138 urine samples had the\n                    <jats:italic toggle=\"yes\">CTX-M<\/jats:italic>\n                    gene and were therefore included in this study. These isolates were screened by polymerase chain reaction for the presence of 14 extra-intestinal virulence factors, class 1 and class 2 integrons, and to identify their phylogenetic groups. Multi-locus sequence typing (MLST) of the strains and susceptibility testing (disc diffusion method) were also performed. Virulence factor\n                    <jats:italic toggle=\"yes\">iutA<\/jats:italic>\n                    was the most frequent determinant identified (86.7%), and the majority of CTX-M-producing strains (n = 5) carried class 1 integrons. MLST allowed us to discriminate four known sequence types (ST131, ST555, ST602, ST155) and three novel sequence types (ST3847, ST3848, ST4181). To the best of our knowledge, this is the first study to report uropathogenic CTX-M-producing\n                    <jats:italic toggle=\"yes\">E coli<\/jats:italic>\n                    ST131 in cats in Italy. Accurate diagnostics and prudent use of antimicrobials are recommended to avoid the spread of multidrug-resistant pathogens in veterinary medicine and to prevent their transmission to humans.\n                  <\/jats:p>","DOI":"10.1177\/1098612x14527103","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T22:19:36Z","timestamp":1394662776000},"page":"966-971","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetic and phenotypic characterisation of\n                    <i>Escherichia coli<\/i>\n                    producing cefotaximase-type extended-spectrum \u03b2-lactamases: first evidence of the ST131 clone in cats with urinary infections in Italy"],"prefix":"10.1177","volume":"16","author":[{"given":"Patrizia","family":"Nebbia","sequence":"first","affiliation":[{"name":"University of Turin, Turin, 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