{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:38:26Z","timestamp":1792579106622,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    A 2-month-old kitten exhibited simultaneously an imperforate anus, hypospadias, rectourethral fistula and genital dysgenesis (penis restricted to the glans, absence of prepuce and bifid scrotum). Surgical correction consisted of separation of the urinary and digestive tracts, perineal urethrostomy and connection of the rectum to the newly made anal opening. Pathological examination of the testes, conventionally removed at 9 months of age, showed no mature spermatozoa and underdevelopment of germ and Leydig cells. In humans, the absence of an anal opening in association with abnormal sexual development defines the urorectal septum malformation sequence. Here, we describe the first case of this syndrome in a kitten with a normal male karyotype (38,XY) and a normal coding sequence for the\n                    <jats:italic toggle=\"yes\">SRY<\/jats:italic>\n                    gene. Both the rectourethral fistula and observed genital abnormalities might have been induced by a disturbance in the hedgehog signalling pathway. However, although four polymorphic sites were identified by\n                    <jats:italic toggle=\"yes\">DHH<\/jats:italic>\n                    gene sequencing, none cosegregated with the malformation.\n                  <\/jats:p>","DOI":"10.1177\/1098612x14529958","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T02:21:34Z","timestamp":1397096494000},"page":"1016-1019","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Partial urorectal septum malformation sequence in a kitten with disorder of sexual development"],"prefix":"10.1177","volume":"16","author":[{"given":"Brice S","family":"Reynolds","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital CHUVAC, University of Toulouse, INP-ENVT, Toulouse, France"},{"name":"Clinical Research Unit, University of Toulouse, INP-ENVT, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Pain","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital CHUVAC, University of Toulouse, INP-ENVT, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Meynaud-Collard","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital CHUVAC, University of Toulouse, INP-ENVT, Toulouse, France"},{"name":"Clinical Research Unit, University of Toulouse, INP-ENVT, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Nowacka-Woszuk","sequence":"additional","affiliation":[{"name":"Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Szczerbal","sequence":"additional","affiliation":[{"name":"Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Switonski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chastant-Maillard","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital CHUVAC, University of Toulouse, INP-ENVT, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1982.181.09.925a"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810382093"},{"key":"e_1_3_3_4_2","first-page":"629","article-title":"Reproductive tract anomalies in 2 male cats","volume":"65","author":"Hakala JE.","year":"1984","unstructured":"Hakala JE. 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Cornell Vet 1992; 82: 141\u2013153.","journal-title":"Cornell Vet"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31925"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1510"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.11.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00024.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10180"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10577-011-9254-z"},{"key":"e_1_3_3_16_2","first-page":"1993","volume-title":"GeneReviews","author":"Ostrer H","unstructured":"Ostrer H. 46,XY disorder of sex development and 46,XY complete gonadal dysgenesis. In: Pagon RA, Adam MP, Bird TD, et al (eds). GeneReviews. Seattle: University of Washington, 1993\u20132013."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00480-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00233.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.26373"},{"key":"e_1_3_3_20_2","first-page":"145","volume-title":"Hereditas 1980","volume":"92","author":"Ford CE","unstructured":"Ford CE, Pollock DL, Gustavsson I. Proceedings of the first international conference for the standardisation of banded karyotypes of domestic animals. Hereditas 1980; 92: 145\u2013162."}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X14529958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X14529958","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X14529958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:43:30Z","timestamp":1792575810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X14529958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1177\/1098612X14529958"],"URL":"https:\/\/doi.org\/10.1177\/1098612x14529958","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}