{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:57:11Z","timestamp":1793444231457,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Obstructive feline idiopathic cystitis is a common emergency in small animal practice. There is evidence for a defective glycosaminoglycan layer in the urinary bladder of affected cats. The aim of this study was to investigate the effect of intravesical pentosan polysulfate sodium (PPS) in cats with obstructive feline idiopathic cystitis in a randomised, placebo-controlled, blinded clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-five cats with obstructive feline idiopathic cystitis were enrolled into the study. On day 0, cats were randomised to receive either 30\u2009mg PPS in saline (18 cats) or saline alone as placebo (17 cats) at the time of indwelling urinary catheter placement and then after 24 and 48\u2009h. The catheter was clamped for 30\u2009mins after administration before connecting it to a sterile urine collection system. The procedure was repeated after 24 and 48\u2009h, and then the indwelling catheter was removed. Treatment success was assessed via the incidence of recurrent urethral obstruction, results of a scoring system for physical examination and daily urinalysis from day 0 to 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Recurrent urethral obstruction occurred in 3\/18 cats of the verum group and 3\/17 of the placebo group (\n                      <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                      =\u20091.000). The verum group showed a significantly lower degree of microscopic haematuria between day 5 and day 0 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2a7d0.05). The placebo group showed a significantly lower degree of dipstick haematuria between day 5 and day 0 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2a7d0.05). There was no difference in the clinical score between the groups in the investigated time period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Intravesical instillation of PPS three times within 48\u2009h in the chosen dose had no influence on the incidence of recurrent urethral obstruction and clinical signs in cats with obstructive feline idiopathic cystitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x15588934","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T22:00:32Z","timestamp":1435356032000},"page":"492-500","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of intravesical pentosan polysulfate sodium in cats with obstructive feline idiopathic cystitis"],"prefix":"10.1177","volume":"18","author":[{"given":"Mareike","family":"Delille","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, LMU University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, LMU University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf S","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, LMU University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, LMU University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"Dorsch","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, LMU University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.03.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0732.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.6.843"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.08.006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32495-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182044"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2004.02.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39897-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(77)90284-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.4.F540"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.09.008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50212-3"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00322-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38437-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.08.001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(84)50053-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50079-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.06.007"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.10.006"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00911.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666060-00006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.170"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.03384.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2003.09.007"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.09.003"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13510918"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.11.1261"},{"key":"e_1_3_3_29_2","unstructured":"Janssen Pharmaceuticals. Elmiron (pentosan polysulfate sodium) 100\u2009mg capsules. http:\/\/www.orthoelmiron.com\/ (2012 accessed Feburary 25 2015)."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.10.071"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01586-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986706777452470"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64909-9"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66981-9"},{"key":"e_1_3_3_35_2","first-page":"713","article-title":"Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion","volume":"539","author":"Chiang G","year":"2003","unstructured":"Chiang G, Patra P, Letourneau R, et al. Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion. Adv Exp Med Biol 2003; 539: 713\u2013729.","journal-title":"Adv Exp Med Biol"},{"key":"e_1_3_3_36_2","first-page":"93","article-title":"Analysis of long-term Elmiron therapy for interstitial cystitis","volume":"49","author":"Hanno PM","year":"1997","unstructured":"Hanno PM. Analysis of long-term Elmiron therapy for interstitial cystitis. Urol Clin North Am 1997; 49: 93\u201399.","journal-title":"Urol Clin North Am"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00714-0"},{"key":"e_1_3_3_38_2","first-page":"39","article-title":"Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis","volume":"50","author":"Hwang P","year":"1997","unstructured":"Hwang P, Auclair B, Beechinor D, et al. Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis. Urol Clin North Am 1997; 50: 39\u201343.","journal-title":"Urol Clin North Am"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.2.287"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/00498250500230586"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80116-5"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35629-X"},{"key":"e_1_3_3_43_2","first-page":"690","article-title":"Randomized, placebo-controlled clinical trial of pentosan polysulfate sodium for treatment of feline interstitial (idiopathic) cystitis","volume":"23","author":"Chew D","year":"2009","unstructured":"Chew D, Bartges J, Adams L, et al. Randomized, placebo-controlled clinical trial of pentosan polysulfate sodium for treatment of feline interstitial (idiopathic) cystitis. J Vet Intern Med 2009; 23: 690.","journal-title":"J Vet Intern Med"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.03.004"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13477414"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.8.1140"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X15588934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X15588934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X15588934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:41:25Z","timestamp":1792582885000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X15588934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1177\/1098612X15588934"],"URL":"https:\/\/doi.org\/10.1177\/1098612x15588934","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}