{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:47:33Z","timestamp":1792583253161,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the feasibility and efficacy of serially administered adipose-derived mesenchymal stem cells (MSCs) in an experimental feline asthma model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Allergic asthma was acutely induced with Bermuda grass allergen in six purpose-bred cats. Five intravenous infusions of allogeneic MSCs (n\n                      <jats:italic toggle=\"yes\">=<\/jats:italic>\n                      4; MSC-treated) or saline (n\n                      <jats:italic toggle=\"yes\">=<\/jats:italic>\n                      2; placebo-treated) were administered over the first 130 days after asthma induction. Infusions contained 2 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      , 4 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      , 4.7 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      , 1 \u00d7 10\n                      <jats:sup>7<\/jats:sup>\n                      and 1 \u00d7 10\n                      <jats:sup>7<\/jats:sup>\n                      cryopreserved MSCs\/cat. For thoracic imaging additional cats were enrolled as control groups: four untreated, experimentally asthmatic cats (combined with placebo-treated cats), and six healthy, non-asthmatic cats. Outcome measures included airway eosinophilia, pulmonary mechanics, thoracic computed tomography and several immunologic assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cats were assessed for 9 months after treatment. At early points, airway eosinophil percentage was not affected by MSC administration (post-treatment average of days 12, 26, 47, 108 and 133 in MSC-treated cats was 41 \u00b1 15% and in placebo-treated cats it was 34 \u00b1 16%). By month 9, eosinophil percentages in all MSC-treated cats decreased to normal reference intervals (MSC-treated 6%; placebo-treated 20%; normal &lt;17%). Diminished airway hyper-responsiveness was noted in all MSC-treated compared with placebo-treated cats at day 133 (dose of methacholine to double baseline airway resistance: MSC-treated median 22.9 mg\/ml [range 6.4\u201364.0]; individual placebo-treated cats 1.1 and 5.0 mg\/ml). Lung attenuation (mean \u00b1 SEM MSC-treated \u2212865 \u00b1 12 Hounsfield units [HU]; untreated asthmatics \u2212820 \u00b1 11 HU;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004) and bronchial wall thickening scores (median [interquartile range] MSC-treated 0 [0\u20131.5]; untreated asthmatic 11.6 [7.3\u201327.3];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.010) were significantly reduced in MSC-treated vs untreated asthmatic cats, consistent with decreased airway remodeling at month 9. No clear immunologic mechanisms by which MSCs act were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>MSCs may have a delayed effect in reducing airway inflammation, airway hyper-responsiveness and remodeling in experimentally induced asthmatic cats. Results warrant additional investigation of MSC therapy for asthma in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x15604351","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T20:43:57Z","timestamp":1442522637000},"page":"981-990","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study"],"prefix":"10.1177","volume":"18","author":[{"given":"Julie E","family":"Trzil","sequence":"first","affiliation":[{"name":"IndyVet Emergency and Specialty Hospital, Indianapolis, Indiana, USA"},{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Masseau","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L","family":"Webb","sequence":"additional","affiliation":[{"name":"Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Hoon","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Dodam","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M","family":"Quimby","sequence":"additional","affiliation":[{"name":"Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W","family":"Dow","sequence":"additional","affiliation":[{"name":"Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol R","family":"Reinero","sequence":"additional","affiliation":[{"name":"Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"},{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080654"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.04.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181b91654"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02509.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910720107"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0513"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00182.2009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.656"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.3.205"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.03.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.07.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt198"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.01.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1111"},{"key":"e_1_3_2_18_2","volume-title":"Symposium of the Veterinary Comparative Respiratory Society","author":"Chang CH","year":"2011","unstructured":"Chang CH, Eason B, DeClue AE, et al. Feline T regulatory cells in bronchoalveolar lavage fluid and whole blood in healthy and experimentally asthmatic cats [abstract]. Symposium of the Veterinary Comparative Respiratory Society 2011; Vienna, Austria."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.05.014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13476705"},{"key":"e_1_3_2_21_2","first-page":"1520","article-title":"High resolution computed tomography in early scleroderma lung disease","volume":"18","author":"Warrick JH","year":"1991","unstructured":"Warrick JH, Bhalla M, Schabel SI, et al. High resolution computed tomography in early scleroderma lung disease. J Rheumatol 1991; 18: 1520\u20131528.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80535-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.1979.4310076"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.12.045"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(03)00049-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.011221"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.11.001"},{"key":"e_1_3_2_28_2","first-page":"19","article-title":"Fate of intravenously injected mesenchymal stem cells and significance for clinical application","volume":"130","author":"Wagner B","year":"2013","unstructured":"Wagner B, Henschler R. Fate of intravenously injected mesenchymal stem cells and significance for clinical application. Adv Biochem Eng Biotechnol 2013; 130: 19\u201337.","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-069716"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130230"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2010.06.007"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.31.3.1"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:27:1:045"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0100"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-008-0001-x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000045055.63901.A9"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3838"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X15604351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X15604351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X15604351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:36:31Z","timestamp":1792582591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X15604351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,10]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1177\/1098612X15604351"],"URL":"https:\/\/doi.org\/10.1177\/1098612x15604351","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,10]]}}}