{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:47:34Z","timestamp":1792583254707,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.046) and COX-2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007) was higher in metastases than in primary tumors. COX-2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.089), HER-2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012) and histologic grade (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.080) were correlated with OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases. Histologic grade, HER-2 status and COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x15610367","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T15:34:09Z","timestamp":1444750449000},"page":"1003-1012","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms"],"prefix":"10.1177","volume":"18","author":[{"given":"Cecilia B","family":"De Campos","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV\/UNESP) \u2013 Jaboticabal Campus, Jaboticabal, Brazil"},{"name":"Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine A","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado O","family":"Gamba","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleidice E","family":"Lavalle","sequence":"additional","affiliation":[{"name":"Veterinary Hospital, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovanni D","family":"Cassali","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1984.185.02.201"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch12"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02727.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-072160558-6.50029-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(86)90107-7"},{"key":"e_1_3_2_7_2","first-page":"1","volume-title":"Histological classification of mammary tumors of the dog and the cat","author":"Misdorp W","year":"1999","unstructured":"Misdorp W, Else RW, Hellm\u00e9n E, et al. 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