{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:26:53Z","timestamp":1777850813943,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Practical relevance<\/jats:title>\n                    <jats:p>Cat breeders aim to suppress the sexual cycle for a defined period. This is a challenge as most preparations available for this intention are orally administered progestins; however, these drugs may have side effects, especially when used over a long period of time. Long-acting gonadotropin-releasing hormone agonist implants have been used successfully to suppress the oestrous cycle in cats for a longer period. After removal of the implant, the duration of action was shortened; however, the re-occurrence of normal cyclicity cannot be foreseen. The search for alternatives is therefore ongoing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical challenges<\/jats:title>\n                    <jats:p>Another possibility for oestrus control is orally administered melatonin preparations; however, previous studies have shown that the effect was not satisfactory. After subcutaneous application of a melatonin implant developed for induction of oestrus in sheep (Melovine; Ceva Sant\u00e9 Animale), duration of oestrus suppression was shown to differ highly in individuals and in some cases no effect was observed. Nevertheless, it is used for short-term oestrus suppression in female cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This article provides an overview of recent studies and clinical experiences of the use of melatonin as a contraceptive in cats. It explains the function of melatonin in cats, discusses previous studies, provides clinical experience with Melovine (27 cases) and elucidates advantages and disadvantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence base<\/jats:title>\n                    <jats:p>Information provided in this article is drawn from the published literature and the author\u2019s own clinical experience.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x15610369","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T22:59:26Z","timestamp":1444863566000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of melatonin on the reproductive cycle in female cats: a review of clinical experiences and previous studies"],"prefix":"10.1177","volume":"19","author":[{"given":"Sabine","family":"Sch\u00e4fer-Somi","sequence":"first","affiliation":[{"name":"Centre for Artificial Insemination and Embryo Transfer, Vetmeduni Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-1098612X15610369","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.03.016"},{"key":"bibr2-1098612X15610369","first-page":"132","volume":"7","author":"Henik RA","year":"1985","journal-title":"Compend Contin Educ Small 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