{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:07Z","timestamp":1792799827132,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Program \u201cJuan de la Cierva\u201d of \u2018Ministerio de Economia y Competitividad\u2019, Spain, through a postdoctoral grant.","id":[{"id":"https:\/\/ror.org\/01txxn211","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to characterise the response of acute phase proteins (APPs) in cats seropositive for\n                      <jats:italic toggle=\"yes\">Dirofilaria immitis<\/jats:italic>\n                      and to its endosymbiont bacterium\n                      <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The APPs serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) were measured in 25 seropositive cats and in 16 healthy seronegative cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SAA and Cp concentrations were significantly higher in animals with\n                      <jats:italic toggle=\"yes\">D immitis<\/jats:italic>\n                      seropositivity that exhibited clinical signs related to the disease, and Hp was elevated in all\n                      <jats:italic toggle=\"yes\">D immitis<\/jats:italic>\n                      -seropositive animals. There was no significant correlation between APPs and\n                      <jats:italic toggle=\"yes\">D immitis<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">Wolbachia<\/jats:italic>\n                      species antibody titres.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      An association between feline seropositivity to\n                      <jats:italic toggle=\"yes\">D immitis<\/jats:italic>\n                      and APP response was demonstrated. Increases in serum SAA and Cp concentrations were related to\n                      <jats:italic toggle=\"yes\">D immitis<\/jats:italic>\n                      -associated clinical signs, whereas Hp increased in all seropositive animals.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x15625435","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T20:52:32Z","timestamp":1453150352000},"page":"693-696","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum acute phase proteins in\n                    <i>Dirofilaria immitis<\/i>\n                    and\n                    <i>Wolbachia<\/i>\n                    seropositive cats"],"prefix":"10.1177","volume":"19","author":[{"given":"Ana C","family":"Silvestre-Ferreira","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"},{"name":"Animal and Veterinary Research Centre (CECAV), University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisete","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vilhena","sequence":"additional","affiliation":[{"name":"Animal and Veterinary Research Centre (CECAV), University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"},{"name":"Department of Veterinary Medicine, Vasco da Gama University School Coimbra, Coimbra, Portugal"},{"name":"Baixo Vouga Veterinary Hospital, Segad\u00e3es-\u00c1gueda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J","family":"Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Tvarijonaviciute","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain"},{"name":"Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Montoya-Alonso","sequence":"additional","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences (IUIBS), Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Carret\u00f3n","sequence":"additional","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences (IUIBS), Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Pastor","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(95)02494-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.09.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)00204-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2010.09.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.01.011"},{"key":"e_1_3_3_7_2","first-page":"1","article-title":"Seroprevalence of heartworm (Dirofilaria immitis) in feline and canine hosts from central and northern Portugal","volume":"14","author":"Vieira L","year":"2014","unstructured":"Vieira L, Silvestre-Ferreira AC, Fontes-Sousa AP, et al. 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