{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:02Z","timestamp":1792799822056,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the 90th Anniversary of Chulalongkorn University, Rachadapisek Sompote","id":[{"id":"https:\/\/ror.org\/028wp3y58","id-type":"ROR","asserted-by":"crossref"}]},{"name":"TJ Animal Health (Thailand) Co Ltd, Bangkok, Thailand"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective was to compare urine protein, urine protein to creatinine ratio (UPC) and N-acetyl-\u03b2-D-glucosaminidase (NAG) index between cats with idiopathic cystitis and clinically normal cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Urine and blood samples were collected from 19 clinically normal cats and 19 cats with idiopathic cystitis without azotaemia at the time of first presentation. Urine protein, urine creatinine and UPC were measured. Additionally, the urinary NAG concentration was measured using the colorimetric method, and the NAG index was calculated by dividing the urinary NAG concentration by the urine creatinine ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Urine protein concentration (mean \u00b1 SEM) was four times higher in cats with idiopathic cystitis (218.29 \u00b1 58.95) than in clinically normal cats (56.13 \u00b1 9.95) (P &lt;0.05). The UPC (mean \u00b1 SEM) of cats with idiopathic cystitis (0.70 \u00b1 0.19) was also five times higher than that of clinically normal cats (0.14 \u00b1 0.02) (P &lt;0.05). The mean \u00b1 SEM NAG index in cats with idiopathic cystitis (4.79 \u00b1 1.53 U\/g) was two times higher than that in clinically normal cats (2.14 \u00b1 0.48 U\/g). The log UPC was positively correlated with the log NAG index in cats with idiopathic cystitis at moderate levels (r\n                      <jats:sup>2<\/jats:sup>\n                      = 0.512;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Cats with idiopathic cystitis had increased amounts of urine protein and an increased UPC. Further study is needed to address the role of urinary NAG and its relationship with glycosaminoglycan levels in cats with idiopathic cystitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x16663593","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T22:00:58Z","timestamp":1471557658000},"page":"869-875","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Urine protein, urine protein to creatinine ratio and N-acetyl-\u03b2-D-glucosaminidase index in cats with idiopathic cystitis vs healthy control cats"],"prefix":"10.1177","volume":"19","author":[{"given":"Isadee","family":"Panboon","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sariya","family":"Asawakarn","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosama","family":"Pusoonthornthum","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00288.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.08.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.2432"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14530212"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0732.x"},{"key":"e_1_3_2_7_2","first-page":"264","volume-title":"BASAVA manual of canine and feline nephrology and urology","author":"Buffington CA","year":"2007","unstructured":"Buffington CA, Chew DJ. Management of non-obstractive idiopathic\/interstitial cystitis in cats. In: Elliott J, Grauer GF (eds). BASAVA manual of canine and feline nephrology and urology. 2nd ed. India: Replika Press, 2007, pp 264\u2013281.","edition":"2"},{"key":"e_1_3_2_8_2","first-page":"75","article-title":"The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment","volume":"48","author":"Skalova S.","year":"2005","unstructured":"Skalova S. The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. 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