{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:06Z","timestamp":1792586406126,"version":"4.5.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The main goal of this study was to test the antiemetic effects of maropitant administered orally 2\u20132.5 h prior to morphine and dexmedetomidine in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n = 39) or no treatment (control; n = 44), 2\u20132.5 h prior to morphine 0.1 mg\/kg and dexmedetomidine 20 \u00b5g\/kg intramuscularly. The incidence of sialorrhea, lip licking, retching and vomiting were recorded after morphine\/dexmedetomidine injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no differences between groups in terms of age or weight. The treated group received a mean \u00b1 SD dose of maropitant of 2.9 \u00b1 0.6 mg\/kg. The incidence of sialorrhea and lip licking was no different between groups. The incidence of retching (control 36% vs maropitant 13%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012) and emesis (control 32% vs maropitant 13%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) was significantly reduced in cats treated with maropitant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Maropitant 8 mg (total dose) administered orally 2\u20132.5 h prior to morphine and dexmedetomidine significantly reduced, but did not eliminate, the incidences of retching and vomiting. Maropitant did not decrease the occurrence of sialorrhea and lip licking, signs that may be indicative of nausea. Maropitant might be useful for morning administration to prevent emesis in outpatient cats requiring sedation or anesthesia; however, dose regimens or interval of administration might require improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x16663595","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T22:00:58Z","timestamp":1471557658000},"page":"876-879","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Maropitant administered orally 2\u20132.5 h prior to morphine and dexmedetomidine reduces the incidence of emesis in cats"],"prefix":"10.1177","volume":"19","author":[{"given":"Manuel","family":"Martin-Flores","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mastrocco","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto M","family":"Lorenzutti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Catholic University of C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Campoy","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pati","family":"Kirch","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenzie M","family":"Learn","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn M","family":"Boesch","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2012.00788.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12414"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15613389"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.248.11.1257"},{"key":"e_1_3_2_6_2","unstructured":"Cerenia (maropitant citrate) [package insert]. Zoetis Kalamazoo MI."},{"key":"e_1_3_2_7_2","article-title":"A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs","author":"Lorenzutti AM","unstructured":"Lorenzutti AM, Martin-Flores M, Litterio NJ, et al. A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs. Can Vet J","journal-title":"Can Vet J"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00952.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.10.1164"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12286"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200721100-00003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.91.87"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14555441"},{"key":"e_1_3_2_14_2","first-page":"A58","article-title":"Assessment of dog owner concern regarding perioperative nausea and vomiting and willingness to pay for antiemetic treatment","volume":"42","author":"Kraus B","year":"2015","unstructured":"Kraus B, Cazlan C. Assessment of dog owner concern regarding perioperative nausea and vomiting and willingness to pay for antiemetic treatment. 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