{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:33:59Z","timestamp":1793014439693,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Iowa State University College of Veterinary Medicine \u2013 Oncology Section","id":[{"id":"https:\/\/ror.org\/04rswrd78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to solicit and compile data from practicing veterinary specialists regarding their use of toceranib in cats with mast cell neoplasia and to provide initial assessment of possible clinical benefit and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The American College of Veterinary Internal Medicine and Oncology listservs were used to solicit data pertaining to cases in which toceranib was used in the treatment of feline mast cell neoplasia. Cases were included if the following data were received: signalment (age, sex, breed), diagnosis of mast cell neoplasia by either cytology or histopathology, anatomic classification of disease (cutaneous, splenic\/hepatic, gastrointestinal, other), previous and concurrent treatment, toceranib dose (mg\/kg) and schedule, duration of therapy, best response and documentation of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Case data from 50 cats with cutaneous (n = 22), splenic\/hepatic (visceral) (n = 10), gastrointestinal (n\u2009=\u200917) or other (n = 1) mast cell neoplasia were received. Clinical benefit was seen in 80% (40\/50), including 86% (19\/22) with cutaneous, 80% (8\/10) with visceral and 76% (13\/17) with gastrointestinal involvement. A majority of cats (n\u2009=\u200935) received glucocorticoids during toceranib treatment. Median duration of treatment in cats experiencing clinical benefit was 36 weeks (range 4\u2013106 weeks), 48 weeks (range 12\u2013199 weeks) and 23 weeks (range 13-81 weeks) for cutaneous, visceral and gastrointestinal cases, respectively. Toceranib was administered at a median dose of 2.5 mg\/kg (range 1.6\u20133.5 mg\/kg); in 90% (45\/50) the drug was given three times per week. Treatment was generally well tolerated with 60% (30\/50) of cats experiencing adverse events. The majority of these events were low-grade (grade 1 or 2) gastrointestinal or hematologic events that resolved with treatment break and\/or dose adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Toceranib appears to be well tolerated in feline patients with mast cell neoplasia. Biologic activity of this drug is evident in the studied cats; however, further prospective studies are needed to elucidate fully its role in treatment of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x17695898","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T05:23:49Z","timestamp":1488777829000},"page":"95-102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia"],"prefix":"10.1177","volume":"20","author":[{"given":"Erika P","family":"Berger","sequence":"first","affiliation":[{"name":"Iowa State University, College of Veterinary Medicine, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M","family":"Johannes","sequence":"additional","affiliation":[{"name":"Iowa State University, College of Veterinary Medicine, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S","family":"Post","sequence":"additional","affiliation":[{"name":"The Veterinary Cancer Center, Norwalk, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Rothchild","sequence":"additional","affiliation":[{"name":"The Veterinary Cancer Center, Norwalk, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Biu","family":"Shiu","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Service\/Veterinary Specialty Center, Middleton, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Service\/Veterinary Specialty Center, Middleton, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie E","family":"Fox","sequence":"additional","affiliation":[{"name":"Iowa State University, College of Veterinary Medicine, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800506"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-4-281"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.12.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/svms.2003.36624"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.04.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00020-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.8.1200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.6.898"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00751.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-4-32"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813476064"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07926.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12246"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.07.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3816"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.05.007"},{"key":"e_1_3_3_18_2","unstructured":"AB Science. 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