{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:00Z","timestamp":1792586700869,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the analgesic effect and absorption of buprenorphine after buccal administration in cats with oral disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six adult client-owned cats with chronic gingivostomatitis (weighing 5.1 \u00b1 1.1 kg) were recruited for a randomised, prospective, blinded, saline-controlled, crossover study. Pain scores, dental examination, stomatitis score and buccal pH measurement were conducted on day 1 under sedation in all cats. On day 2, animals were randomised into two groups and administered one of the two treatments buccally (group A received buprenorphine 0.02 mg\/kg and group B received 0.9% saline) and vice versa on day 3. Pain scores and food consumption were measured at 30, 90 and 360 mins after the administration of buprenorphine. Blood samples were taken at the same time and plasma buprenorphine concentration was measured by liquid chromatography\u2013mass spectrometry. Data were statistically analysed as non-parametric and the level of significance was set as\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no major side effects after buprenorphine administration. Buccal pH values ranged between 8.5 and 9.1 and the stomatitis disease activity index between 10 and 22 (17.8 \u00b1 4.5), with the scale ranging from 0\u201330. The maximum buprenorphine plasma concentration (14.8 ng\/ml) was observed 30 mins after administration and there was low inter-individual variability. There was a significant difference between baseline pain scores compared with pain scores after buprenorphine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05), and between the saline and buprenorphine group at 30 mins (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) and 90 mins (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). There was also a significant effect of the stomatitis index on the pain score. Regarding the pharmacokinetic parameters, cats with stomatitis showed lower bioavailability and shorter absorption half-life after buccal administration of buprenorphine compared with normal cats in previous studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Buccal administration of buprenorphine in cats with gingivostomatitis produces an analgesic effect and low inter-individual variability in plasma concentration, and it can be incorporated in their multimodal analgesia plan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x17727234","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T09:26:23Z","timestamp":1505208383000},"page":"704-710","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of analgesic effect and absorption of buprenorphine after buccal administration in cats with oral disease"],"prefix":"10.1177","volume":"20","author":[{"given":"Thaleia-Rengina","family":"Stathopoulou","sequence":"first","affiliation":[{"name":"Clinical Services and Sciences, Royal Veterinary College, Hatfield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kouki","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki School of Veterinary Medicine, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno H","family":"Pypendop","sequence":"additional","affiliation":[{"name":"Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atholl","family":"Johnston","sequence":"additional","affiliation":[{"name":"Queen Mary University of London and Analytical Services International, St George\u2019s, University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serafeim","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki School of Veterinary Medicine, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Pelligand","sequence":"additional","affiliation":[{"name":"Clinical Services and Sciences, Royal Veterinary College, Hatfield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.21.601"},{"key":"e_1_3_2_3_2","first-page":"552","article-title":"Factors influencing the postoperative use of analgesics in dogs and cats by Canadian veterinarians","volume":"37","author":"Dohoo SE","year":"1996","unstructured":"Dohoo SE, Dohoo IR. 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