{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:03Z","timestamp":1792586703342,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The pharmacokinetics of praziquantel and pyrantel pamoate has never been reported in cats. The present study was designed to establish the plasma concentration\u2013time profile and to derive pharmacokinetic data for a combined formulation of praziquantel and pyrantel in cats, after a single, oral administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two clinically healthy adult cats were used, each receiving a single oral dose of praziquantel (8.5 mg\/kg) and pyrantel (100 mg\/kg). Blood samples were collected at regular time points up to 48 h post-dosing. Plasma concentrations of praziquantel and pyrantel were measured using a liquid chromatography\u2013mass spectrometry\u2013high-throughput screening method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinical examination of all cats did not reveal any side effects after oral administration of these medications. The terminal half-life for praziquantel and pyrantel was 1.07 and 1.36 h, respectively. Praziquantel peak concentration (C\n                      <jats:sub>max<\/jats:sub>\n                      ) was 1140 \u03bcg\/ml, reached at 1.22 h. The plasma concentrations of pyrantel after oral administration were low with a mean C\n                      <jats:sub>max<\/jats:sub>\n                      of 0.11 \u03bcg\/ml, reached at a T\n                      <jats:sub>max<\/jats:sub>\n                      of 1.91 h. Pyrantel showed a very limited absorption as pamoate salt, suggesting permanence and efficacy inside the gastrointestinal tract, where the adult stages of most parasitic nematodes reside.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Pyrantel showed a very limited absorption as pamoate salt. Praziquantel was rapidly absorbed following oral administration and the concentrations achieved suggest that praziquantel could be an effective and safe medication in cats. Although some resistance problems are arising as a result of their long use, these anthelminthic products can still play a major role in parasitic control, especially in geographical areas where the high cost of newer treatments or necessity of parenteral administration could decrease the number of treated animals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x17734065","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T04:57:31Z","timestamp":1507697851000},"page":"900-904","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacokinetics of praziquantel and pyrantel pamoate combination following oral administration in cats"],"prefix":"10.1177","volume":"20","author":[{"given":"Alexandra","family":"Arion","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Manastur, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Fern\u00e1ndez-Var\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M","family":"C\u00e1rceles","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Gagyi","sequence":"additional","affiliation":[{"name":"SC VIM Spectrum, Corunca, Mures\u201a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Ognean","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Manastur, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1053","volume-title":"Veterinary pharmacology and therapeutics.","author":"Riviere JE","year":"2009","unstructured":"Riviere JE, Papich MG. 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