{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:51:31Z","timestamp":1789743091392,"version":"4.0.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["12\/19614-6"],"award-info":[{"award-number":["12\/19614-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["13\/06471-5"],"award-info":[{"award-number":["13\/06471-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to establish ultrasound criteria for the diagnosis of autosomal dominant polycystic kidney disease (ADPKD) in Persian cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty-two Persian cats were assessed using renal ultrasound and genotyped for the C\u2192A transversion in exon 29 of\n                      <jats:italic toggle=\"yes\">PKD1<\/jats:italic>\n                      . The animals were also submitted to hematological characterization, serum biochemistry analyses and urinalysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age, sex and neutering status did not differ between ADPKD (n = 12) and non-ADPKD (n = 70) cats. After integrated molecular genetics\/ultrasonographic analysis, the presence of at least one renal cyst was sufficient to establish a diagnosis of ADPKD in animals up to 15 months of age. Two or more cysts were required for diagnosis in cats aged 16\u201332 months, and at least three cysts warranted diagnosis of ADPKD in animals aged 33\u201349 months. Finally, four or more cysts led to diagnosis in cats aged 50\u201366 months. Although cats with ADPKD exhibited higher serum calcium levels than non-affected cats, hematological, urinalysis and other biochemical parameters did not differ between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Integrated analyses of imaging and molecular genetics data enabled, for the first time, the establishment of age-based ultrasonographic criteria for the diagnosis of ADPKD in Persian cats. The development of imaging criteria is particularly relevant and useful in the clinical setting given the current limitations to access and the cost of molecular genetics-based diagnostic tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18764591","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T10:27:53Z","timestamp":1523615273000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Age-based ultrasonographic criteria for diagnosis of autosomal dominant polycystic kidney disease in Persian cats"],"prefix":"10.1177","volume":"21","author":[{"given":"Juliana M","family":"Guerra","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Nucleus of Quantitative Pathology, Pathology Center, Adolfo Lutz Institute, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana F","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre GT","family":"Daniel","sequence":"additional","affiliation":[{"name":"Gattos \u2013 Specialized Feline Medicine Clinic, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arine","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Gattos \u2013 Specialized Feline Medicine Clinic, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia C","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac","family":"de Castro","sequence":"additional","affiliation":[{"name":"Disciplines of Molecular Medicine and Nephrology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz F","family":"Onuchic","sequence":"additional","affiliation":[{"name":"Disciplines of Molecular Medicine and Nephrology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Cogliati","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu017"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.59"},{"key":"e_1_3_3_5_2","unstructured":"Harris PC Torres VE. 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