{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:47Z","timestamp":1792597547701,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Thrombolytic therapy is a treatment of choice for people with acute ischemic events, but is uncommonly administered for feline aortic thromboembolism (FATE). This study reports selected clinical data and outcomes of acute FATE treated with tissue plasminogen activator (TPA). A reference group treated with current standard of care (SOC) was analyzed for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of FATE in two academic hospitals. TPA-treated cats with two or more limbs (n = 16) affected were compared with a SOC-treated group with two or more limbs affected (n = 38). A limb score based on motor function and pulse quality was calculated for each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Limb score and proportion of congestive heart failure at admission was similar in both groups. Time from FATE to admission was shorter in the TPA group, with a median of 3 h (range 0\u20136 h) vs 6 h (range 0\u201348 h;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0004). The most common regimen received for TPA was 1 mg\/kg over 1 h. Other treatments were similar to those of the SOC group and included analgesia, thromboprophylaxis and furosemide. Documented complications for TPA-treated cats included reperfusion injury (5\/10) and acute kidney injury (AKI; 3\/10). Discharge proportion rate was 44% (TPA) vs 29% (SOC;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.351). There were no differences in short-term survival rate (56.2% vs 39.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.369), clinical improvement (56.2% vs 31%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.122), rates of reperfusion injury (50% vs 50%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.00) or AKI (30% vs 27%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.00) between the TPA-treated and SOC groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Survival and complication rates of TPA-treated cats and SOC-treated cats for acute FATE were similar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18778157","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T04:46:30Z","timestamp":1527569190000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Thrombolysis with tissue plasminogen activator (TPA) in feline acute aortic thromboembolism: a retrospective study of 16 cases"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-4387","authenticated-orcid":false,"given":"Julien","family":"Guillaumin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan MB","family":"Gibson","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Goy-Thollot","sequence":"additional","affiliation":[{"name":"University of Lyon, VetAgro Sup, SIAMU, APCSe, F-69280 Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Bonagura","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"260","article-title":"Feline aortic thromboemboli","volume":"18","author":"Pion PD.","year":"1988","unstructured":"Pion PD. Feline aortic thromboemboli. Vet Clin North Am Small Anim Pract 1988; 18: 260\u2013262","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12249"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-6-492"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.1999.0049"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb01326.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.08.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70130-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0720"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2301"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2302"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30139-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2000.tb00010.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50008-6"},{"key":"e_1_3_2_15_2","first-page":"262","article-title":"Feline aortic thromboemboli: T-PA thrombolysis followed by aspirin therapy and rethrombosis","volume":"18","author":"Pion PD.","year":"1988","unstructured":"Pion PD. Feline aortic thromboemboli: T-PA thrombolysis followed by aspirin therapy and rethrombosis. Vet Clin North Am Small Anim Pract 1988; 18: 262\u2013263.","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1986.47.06.1351"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12464458"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1258\/rsmvasc.12.3.202"},{"key":"e_1_3_2_19_2","first-page":"925","volume-title":"Proceedings of the American College of Veterinary Internal Medicine Annual Forum","author":"Pion P","unstructured":"Pion P, Kittleson M, Peterson S, et al. Thrombolysis of aortic thromboembolism in cats using tissue plasminogen activator: clinical data. Proceedings of the American College of Veterinary Internal Medicine Annual Forum; 1987 May 21st, San Diego, CA. Blacksburg, VA: American College of Veterinary Internal Medicine 1987, p 925."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574413513845"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X18778157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X18778157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X18778157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:55:38Z","timestamp":1792594538000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X18778157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1177\/1098612X18778157"],"URL":"https:\/\/doi.org\/10.1177\/1098612x18778157","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]}}}