{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:45Z","timestamp":1792597605772,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to assess serum lipoprotein profiles using rapid single-spin continuous lipoprotein density profiling (CLPDP) in healthy control cats and cats with hepatic lipidosis (HL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis of serum lipoprotein profiles using the CLPDP was performed in 23 cats with HL and 20 healthy control cats. The area under the curve for each lipoprotein fraction, triglyceride (TG)-rich lipoproteins (TRLs), low-density lipoproteins (LDLs) and high-density lipoproteins (HDLs), was calculated. Serum cholesterol and TG concentrations were measured using a clinical chemistry analyzer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum cholesterol and TG concentrations were not significantly different between healthy control cats and cats with HL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.5075 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.2541, respectively). LDL content was significantly higher in cats with HL than in healthy control cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001), while HDL content was significantly lower in cats with HL than in healthy control cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0032). TRL content was not significantly different between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0699). The specific fraction (1.037\u20131.043 g\/ml) within nominal LDL in serum distinguished healthy control cats from cats with HL with a sensitivity of 87% and a specificity of 90%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Serum lipoprotein profiles were altered in cats with HL, even though serum cholesterol and TG concentrations were not significantly different compared with healthy control cats. The CLPDP might be a useful tool for assessing lipid metabolism in cats with HL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18780060","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T05:02:29Z","timestamp":1528088549000},"page":"363-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered lipoprotein profiles in cats with hepatic lipidosis"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-2382","authenticated-orcid":false,"given":"Tomomi","family":"Minamoto","sequence":"first","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary L","family":"Walzem","sequence":"additional","affiliation":[{"name":"Department of Poultry Science and Faculty of Nutrition, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve L","family":"Hill","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold R","family":"Payne","sequence":"additional","affiliation":[{"name":"Image Analysis Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Lidbury","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg M","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.11.014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00097.x"},{"key":"e_1_3_2_4_2","first-page":"1658","volume-title":"Textbook of veterinary internal medicine","author":"Watson PJ","year":"2017","unstructured":"Watson PJ. 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