{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:04Z","timestamp":1792800004218,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"DECHRA Animal Health","id":[{"id":"https:\/\/ror.org\/024409k12","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the analgesic efficacy of methadone vs buprenorphine within the QUAD protocol for anaesthesia in cats undergoing ovariohysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and twenty cats were recruited to an assessor-blinded, randomised clinical trial. Cats received either methadone (5\u2009\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) or buprenorphine (180\u2009\u00b5g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) combined with ketamine, midazolam and medetomidine intramuscularly. Anaesthesia was maintained with isoflurane in oxygen. Atipamezole was administered at extubation. Pain was assessed using the feline Composite Measure Pain Scale (CMPS-F), a dynamic interactive visual analogue scale (DIVAS) and mechanical nociceptive threshold (MNT). Sedation, pain, heart rate and respiratory rate were measured prior to QUAD administration, before intubation, and 2, 4, 6 and 8 h post-QUAD administration. If indicated by the CMPS-F, rescue analgesia was provided with 0.5 mg\/kg of methadone administered intramuscularly. Meloxicam was administered after the last assessment. Differences in pain scores between groups were compared using a two-way repeated-measures ANOVA and requirement for rescue analgesia was compared using a \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cats administered methadone had lower CMPS-F scores over time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). Eighteen of 60 cats required rescue analgesia in the methadone group vs 29\/60 in the buprenorphine group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.028). All cats that received rescue analgesia required it within 6 h post-QUAD administration. There were no differences between groups in MNT or pain measured using the DIVAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Methadone produced clinically superior postoperative analgesia for the first 8 h after neutering than buprenorphine when used within the QUAD protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18798840","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:30:59Z","timestamp":1536913859000},"page":"723-731","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison between methadone and buprenorphine within the QUAD protocol for perioperative analgesia in cats undergoing ovariohysterectomy"],"prefix":"10.1177","volume":"21","author":[{"given":"Meera","family":"Shah","sequence":"first","affiliation":[{"name":"Bristol Veterinary School, Langford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yates","sequence":"additional","affiliation":[{"name":"Greater Manchester RSPCA Hospital, Salford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hunt","sequence":"additional","affiliation":[{"name":"Cave Veterinary Specialists, George\u2019s Farm, West Buckland, Wellington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5159","authenticated-orcid":false,"given":"Jo","family":"Murrell","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School, Langford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.11.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.21.601"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15572970"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15578725"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102834"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00378.x"},{"key":"e_1_3_2_8_2","first-page":"435","article-title":"Pharmacology of methadone and its isomers","volume":"71","author":"Inturrisi CE.","year":"2005","unstructured":"Inturrisi CE. Pharmacology of methadone and its isomers. Minerva Anestesiol 2005; 71: 435\u2013437.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38234-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00062.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.09.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12444743"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2012.00736.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14558893"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.6.844"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12280"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00533.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1998.212.01.61"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.06.008"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S096272860003178X"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.06.002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2005.00677.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15605164"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.225.689"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00259.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2017.09.009"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X18798840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X18798840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X18798840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:26:09Z","timestamp":1792596369000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X18798840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/1098612X18798840"],"URL":"https:\/\/doi.org\/10.1177\/1098612x18798840","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]}}}