{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:47:14Z","timestamp":1792586834402,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007612","name":"Animal Health Trust","doi-asserted-by":"publisher","award":["AHT41_2013"],"award-info":[{"award-number":["AHT41_2013"]}],"id":[{"id":"10.13039\/100007612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to report the prevalence of iatrogenic hypothyroidism, with or without azotaemia, based on the measurement of serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and creatinine concentrations, in hyperthyroid cats undergoing radioiodine (\n                      <jats:sup>131<\/jats:sup>\n                      I) treatment where the\n                      <jats:sup>131<\/jats:sup>\n                      I dose was calculated using a previously described scoring system. A secondary aim of the study was to determine the positive and negative predictive values of serum T4 and TSH concentrations obtained 19 days after treatment in order to predict the development of iatrogenic hypothyroidism 6\u20139 months after\n                      <jats:sup>131<\/jats:sup>\n                      I treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum T4, TSH and creatinine concentrations were measured 19 days and 6\u20139 months after\n                      <jats:sup>131<\/jats:sup>\n                      I treatment. The prevalence of iatrogenic hypothyroidism was assessed with the results obtained 6\u20139 months after\n                      <jats:sup>131<\/jats:sup>\n                      I treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of overt and subclinical hypothyroidism 6\u20139 months after\n                      <jats:sup>131<\/jats:sup>\n                      I treatment was 40.0% (22\/55 cats) and 12.7% (7\/55 cats). Overt hypothyroidism with azotaemia was diagnosed in 8\/55 (14.5%) cats. The positive and negative predictive values for the prediction of the development of iatrogenic hypothyroidism 6\u20139 months after\n                      <jats:sup>131<\/jats:sup>\n                      I treatment were 72.2% and 80.0%, respectively, for a low serum T4 concentration, and 75.0% and 44.6%, respectively, for an increased serum TSH concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      The use of an individualised scoring system is effective in determining the\n                      <jats:sup>131<\/jats:sup>\n                      I dose for the treatment of hyperthyroid cats. However, the prevalence of overt hypothyroidism was higher in comparison with other studies using different dosing protocols. Further studies comparing the efficacy of individualised scoring systems and different fixed doses to determine which method is superior are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18822396","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T01:16:59Z","timestamp":1548206219000},"page":"1149-1156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-8931","authenticated-orcid":false,"given":"Yordan","family":"Fernandez","sequence":"first","affiliation":[{"name":"Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Puig","sequence":"additional","affiliation":[{"name":"Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Powell","sequence":"additional","affiliation":[{"name":"Powell Torrance Diagnostic Services, Higham Gobion, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Seth","sequence":"additional","affiliation":[{"name":"Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.22233\/9781905319893.10"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12157"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13368"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2006.00146.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.207.11.1422"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.4.559"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14646"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2005.12.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.21.711"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0566.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-22652-3.00023-2"},{"key":"e_1_3_3_13_2","first-page":"447","article-title":"Overt or subclinical iatrogenic hypothyroidism in cats: clinical, laboratory, and thyroid scintigraphy findings in 35 cases [abstract]","volume":"29","author":"Peterson ME","year":"2015","unstructured":"Peterson ME, Gutherl JN. 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