{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:48Z","timestamp":1792799868850,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"University of Wisconsin-Madison School of Veterinary Medicine Companion Animal Grant","id":[{"id":"https:\/\/ror.org\/01y2jtd41","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to compare serum phenobarbital concentrations, adverse events and client satisfaction during 14 weeks of transdermal vs oral phenobarbital administration to epileptic cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, fixed-order, crossover pilot study. Nine client-owned cats with presumptive or diagnosed idiopathic epilepsy were enrolled. Oral phenobarbital (PO-PB) was administered for weeks 1\u201314 (median starting dosage of 3.8 mg\/kg [2.0\u20135.4 mg\/kg\/day] q12h); transdermal phenobarbital (TD-PB) was administered for weeks 14\u201328 (median starting dosage 18.8 mg\/kg\/day [17.6\u201324.0 mg\/kg\/day] q12h). Serum phenobarbital concentrations (S-PB) were measured at weeks 2, 14, 16 and 28. Client satisfaction questionnaires and biochemistry were evaluated at 14 and 28 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median S-PB concentrations during oral administration were 21 \u00b5g\/ml (observed range 11\u201340 \u00b5g\/ml) at week 2 and 22 \u00b5g\/ml (8\u201335 \u00b5g\/ml) at week 14, and at the higher TD dosage were 18 \u00b5g\/ml (0\u201342 \u00b5g\/ml) at week 16 and 17 \u00b5g\/ml (7\u201350 \u00b5g\/ml) at week 28. Phenobarbital concentrations were significantly correlated with PO dosage at week 2 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.75,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) but not at weeks 16 and 28. Significantly more dose adjustments were needed during the TD phase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), but 6\/9 owners (67%) still preferred TD to PO administration. Adverse effects were mild and comparable in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Therapeutic S-PB concentrations were achievable in some cats using TD-PB at 18 mg\/kg\/day q12h. Poor correlation between TD dosage and S-PB concentrations was observed and more dosage adjustments were required during TD administration. These findings necessitate close therapeutic drug monitoring if TD-PB is prescribed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18823577","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T09:11:57Z","timestamp":1548666717000},"page":"1181-1187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-2172","authenticated-orcid":false,"given":"Heidi L","family":"Barnes Heller","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A","family":"Trepanier","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Robertson","sequence":"additional","affiliation":[{"name":"UW Veterinary Care Pharmacy, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research, and Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.03.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.09.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2009.00509.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.2.195"},{"key":"e_1_3_3_6_2","first-page":"309","article-title":"Pharmacokinetics of phenobarbital in the cat following multiple oral administration","volume":"54","author":"Cochrane S","year":"1990","unstructured":"Cochrane S, Parent J, Black W, et al. 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