{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:47:18Z","timestamp":1792586838686,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Magnesium has been \u2018the forgotten ion\u2019 for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. The purpose of this study was to investigate whether CKD cats with nephrolithiasis have changes in total serum magnesium concentrations, and whether magnesium disorders may be associated with other electrolyte disturbances, as well as with prognosis. We also aimed to evaluate whether total serum magnesium concentration differs between CKD cats with and without nephrolithiasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Total serum magnesium concentrations were assessed in 42 cats with CKD with stage 1\u20134 nephrolithiasis. The correlation between magnesium and other electrolytes, as well as Kaplan\u2013Meier survival analysis, were performed. We also selected 14 control cats with CKD without nephrolithiasis age-matched with 14 cats with CKD with nephrolithiasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypermagnesemia was observed in 16\/42 (38.1%) and hypomagnesemia in 6\/42 (14.3%) cats. Serum magnesium abnormalities were observed in cats of all stages, and marked hypermagnesemia was noted in cats with stage 4 CKD with nephrolithiasis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). There was a negative correlation between total serum magnesium and ionized calcium (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.64;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01), and a positive correlation between total serum magnesium and serum phosphorus (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.58,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). Cats with CKD with nephrolithiasis and hypomagnesemia or hypermagnesemia had higher mortality than those with normal total serum magnesium concentration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01), regardless of CKD stage. There was no difference in total serum magnesium concentration between CKD cats with and without nephrolithiasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Cats with CKD with nephrolithiasis have magnesium abnormalities. Hypomagnesemia and hypermagnesemia were associated with an increase in mortality, and thus total serum magnesium abnormalities may be used as prognostic factors in these cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x18823588","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T10:19:08Z","timestamp":1548757148000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Total serum magnesium in cats with chronic kidney disease with nephrolithiasis"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-9960","authenticated-orcid":false,"given":"Fernanda Chicharo","family":"Chacar","sequence":"first","affiliation":[{"name":"Internal Medicine, School of Veterinary Medicine and Animal Science\/University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Mery","family":"Kogika","sequence":"additional","affiliation":[{"name":"Internal Medicine, School of Veterinary Medicine and Animal Science\/University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a C","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Internal Medicine, School of Veterinary Medicine and Animal Science\/University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadine K","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Internal Medicine, School of Veterinary Medicine and Animal Science\/University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archivaldo","family":"Reche","sequence":"additional","affiliation":[{"name":"Internal Medicine, School of Veterinary Medicine and Animal Science\/University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"237","article-title":"Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients","volume":"20","author":"Ishimura E","year":"2007","unstructured":"Ishimura E, Okuno S, Yamakawa T, et al. 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