{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:49:19Z","timestamp":1792590559683,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to describe the sedative and some physiological effects of tiletamine\u2013zolazepam following buccal administration (BA) in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine\u2013zolazepam by BA: the low-dose (LD) group consisted of 5 mg\/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg\/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) were recorded at predefined intervals for the next 2 h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0\/7 and 3\/7 for LD and HD groups, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.2). There were significant changes in scores over time for posture, response to clippers and response to manual restraint for both groups, without differences between groups. RR, HR and SAP changed significantly over time. SAP and RR were significantly lower for the HD than for the LD group. No values for hemoglobin saturation &lt;95% were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>BA of tiletamine\u2013zolazepam at the doses studied here is a simple and effective method for chemical restraint in cats, where the LD group had a lower impact on SAP and RR than the HD  group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19827116","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T19:21:00Z","timestamp":1549999260000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Sedative and physiologic effects of tiletamine\u2013zolazepam following buccal administration in cats"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-3327","authenticated-orcid":false,"given":"Pablo","family":"Nejamkin","sequence":"first","affiliation":[{"name":"Hospital for Small Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"},{"name":"Hospital for Large Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Cavilla","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery, Clinical Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Clausse","sequence":"additional","affiliation":[{"name":"General Clinical Surgery Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"},{"name":"Veterinary Research Center of Tandil (CIVETAN, CONICET-CICPBA), Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Landivar","sequence":"additional","affiliation":[{"name":"Hospital for Large Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto M","family":"Lorenzutti","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, Faculty of Agricultural Sciences, Catholic University of C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery, Clinical Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J","family":"Del Sole","sequence":"additional","affiliation":[{"name":"Hospital for Large Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"},{"name":"Veterinary Research Center of Tandil (CIVETAN, CONICET-CICPBA), Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mart\u00edn-Flores","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2010.00555.x"},{"key":"e_1_3_2_3_2","unstructured":"Ilona R Heath S. 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