{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:48:05Z","timestamp":1793119685269,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to report the prevalence of a honeycomb appearance of the spleen in a population of referral cats presented for ultrasound examination, and to determine the diagnostic value of this finding vs the definitive diagnosis, the splenic cytological and haematological results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from the medical records (2016\u20132018) of cats that had an ultrasonographic honeycomb appearance of the spleen, a splenic cytological diagnosis and a complete blood count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-five cats were included. Prevalence of the honeycomb pattern was 6.8%. None of the spleen was considered normal on cytology and four types of lesions were found: lymphoid hyperplasia (64%), neoplasia (16%), extramedullary haematopoiesis (12%) and splenitis (8%). A honeycomb pattern was successfully identified with a linear high-frequency probe in all cats, but only in 36% of cases with the micro-convex probe. Follow-up information was available for four cats, in which the honeycomb appearance persisted up to 105 days after the first examination; there was persistence of the honeycomb pattern in all cases. Cats with a splenic cytological diagnosis of extramedullary haematopoiesis had the lowest haemoglobin plasma concentration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Honeycomb appearance of the spleen is uncommon in cats and, in our study, was systematically associated with cytological alterations; most of the time it was benign (84%). The use of a high-frequency linear probe improves its detection rate. No epidemiological, ultrasonographic or clinical criteria allow differentiation between the different types of infiltration and fine-needle aspiration is therefore recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19837336","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T10:06:06Z","timestamp":1553162766000},"page":"186-192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and diagnostic value of the ultrasonographic honeycomb appearance of the spleen in cats"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-8121","authenticated-orcid":false,"given":"Mathieu","family":"Harel","sequence":"first","affiliation":[{"name":"Diagnostic Imaging Unit, Universit\u00e9 de Lyon, VetAgro Sup, F-69280, Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Touzet","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Unit, Universit\u00e9 de Lyon, VetAgro Sup, F-69280, Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Intensive Care Unit (SIAMU), Universit\u00e9 de Lyon, VetAgro Sup, APCSe, F-69280, Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie M","family":"S\u00e9gard-Weisse","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Unit, Universit\u00e9 de Lyon, VetAgro Sup, F-69280, Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"239","volume-title":"Atlas of small animal ultrasonography","author":"Hecht S","year":"2015","unstructured":"Hecht S, Mai W. Spleen. In: Penninck D, D\u2019Anjou MA (eds). Atlas of small animal ultrasonography. 2nd ed. Ames, IA: John Wiley, 2015, pp 239\u2013258.","edition":"2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4867-1.00010-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00967.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12127"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00059.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01725.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1991.tb00093.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17697483"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-168903-5\/50006-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13508947"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00320.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00115.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.5.690"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01990.x"},{"key":"e_1_3_2_16_2","first-page":"613","article-title":"Comparative aspects of splenic microcirculatory pathways in mammals: the region bordering the white pulp","volume":"7","author":"Schmidt EE","year":"1993","unstructured":"Schmidt EE, MacDonald IC, Groom AC. 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