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Infected cats typically present with a history of outdoor lifestyle and hunting behaviour, and cutaneous granulomas are most commonly observed. The aim of this study is to describe an outbreak of tuberculous disease commencing with six young cats, living exclusively indoors in five different households across England, being presented to separate veterinarians across the UK with a variety of clinical signs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Investigations into the pyogranulomatous lesions, lymphadenopathy and\/or pulmonary disease of these cases consistently identified infection with\n                      <jats:italic toggle=\"yes\">M bovis<\/jats:italic>\n                      . Infection was confirmed by PCR, where possible, or was indicated with a positive interferon-gamma release assay (IGRA), where material for PCR was unavailable. In-contact, cohabiting cats were screened by IGRA and follow-up testing was undertaken\/advised where results were positive. A lifestyle investigation was undertaken to identify the source of infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six clinically sick cats and seven in-contact cats were identified with evidence of\n                      <jats:italic toggle=\"yes\">M bovis<\/jats:italic>\n                      infection. Five clinical cases were either too sick to treat or deteriorated despite therapy, giving a mortality rate of 83%. Lifestyle investigations revealed the common factors between clusters to be that affected cats had mycobacterial infections speciated to\n                      <jats:italic toggle=\"yes\">M bovis<\/jats:italic>\n                      , were exclusively indoor cats and were fed a commercially available raw food product produced by a single manufacturer. The Food Standards Agency, Animal &amp; Plant Health Agency, Public Health England and the food manufacturer concerned have been notified\/informed. Other possible sources of exposure for these cats to\n                      <jats:italic toggle=\"yes\">M bovis<\/jats:italic>\n                      were explored and were excluded, including wildlife contact, access to raw milk, the presence of rodent populations inside the buildings in which the cats lived and exposure to known infectious humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      Upon investigations, our results provide compelling, if circumstantial, evidence of an association between the commercial raw diet of these cats and their\n                      <jats:italic toggle=\"yes\">M bovis<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19848455","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T19:01:20Z","timestamp":1557774080000},"page":"667-681","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Tuberculosis due to\n                    <i>Mycobacterium bovis<\/i>\n                    in pet cats associated with feeding a commercial raw food diet"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-2907","authenticated-orcid":false,"given":"Conor","family":"O\u2019Halloran","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, 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