{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:21Z","timestamp":1792800021526,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis","award":["Residency Research Grant 2015-51-R"],"award-info":[{"award-number":["Residency Research Grant 2015-51-R"]}],"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to assess the effects of famciclovir administration in cats with spontaneously acquired acute upper respiratory tract disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-four kittens with clinical signs of acute upper respiratory tract disease were randomly allocated to receive doxycycline (5 mg\/kg PO q12h) alone (group D; n = 12) or with famciclovir (90 mg\/kg PO q12h; group DF; n = 12) for up to 3 weeks. Clinical disease severity was scored at study entry and daily thereafter. Oculo-oropharyngeal swabs collected at study entry and exit were assessed using quantitative PCR for nucleic acids of feline herpesvirus type 1 (FHV-1), feline calicivirus (FCV),\n                      <jats:italic toggle=\"yes\">Chlamydia felis, Bordetella bronchiseptica<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Mycoplasma felis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (range) age of cats was 1.5 (1\u20136) months in group D vs 1.6 (1\u20135) months in group DF (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.54). Pathogens detected in oculo-oropharyngeal swabs at study entry included FCV (n = 13\/24; 54%),\n                      <jats:italic toggle=\"yes\">M felis<\/jats:italic>\n                      (n = 8\/24; 33%), FHV-1 (n = 7\/24; 29\n                      <jats:italic toggle=\"yes\">%<\/jats:italic>\n                      ),\n                      <jats:italic toggle=\"yes\">C felis<\/jats:italic>\n                      (n = 7\/24; 29%) and\n                      <jats:italic toggle=\"yes\">B bronchiseptica<\/jats:italic>\n                      (n = 3\/24; 12%). Median (range) duration of clinical signs was 11.5 (3\u201321) days in group DF and 11 (3\u201321) days in group D (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.75). Median (range) total disease score at the end of the study did not differ between groups (group D 1 [1\u20131] vs group DF 1 [1\u20133];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>This study revealed no significant difference in response to therapy between cats treated with doxycycline alone or with famciclovir; cats improved rapidly in both groups. However, identification of FHV-1 DNA was relatively uncommon in this study and clinical trials focused on FHV-1-infected cats are warranted to better evaluate famciclovir efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19857587","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T09:19:56Z","timestamp":1561627196000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-9463","authenticated-orcid":false,"given":"Lucy","family":"Kopecny","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Maggs","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M","family":"Leutenegger","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, West Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynelle R","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006063"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2003.08.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.04.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02172.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0084"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.05.015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.2.519-523.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.1550"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063879901100203"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1999.214.04.502"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.08.001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15569615"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00187-11"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2018.05.001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.05.018"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.07.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.1.85"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.11.012"},{"key":"e_1_3_3_20_2","first-page":"418","article-title":"Treatment of ocular nasal, and dermatologic disease attributable to feline herpesvirus 1 with famciclovir","volume":"11","author":"Thomasy SM","year":"2008","unstructured":"Thomasy SM, Maggs DJ. 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