{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:30Z","timestamp":1792787730282,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Netherlands Organization for Health Research and Development","award":["NWO Zon\/MW number 16004121"],"award-info":[{"award-number":["NWO Zon\/MW number 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       <jats:italic toggle=\"yes\">PPAR-\u03b3<\/jats:italic>\n                      ), fatty acid synthase (\n                      <jats:italic toggle=\"yes\">FASN<\/jats:italic>\n                      ) and sterol regulatory element-binding factor (\n                      <jats:italic toggle=\"yes\">SREBF1<\/jats:italic>\n                      ) were evaluated using quantitative RT-PCR in liver tissue of six cats with FHL and compared with the liver tissue of eight healthy cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In liver tissue,\n                      <jats:italic toggle=\"yes\">PPAR-\u03b1, PPAR-\u03b3<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">FASN<\/jats:italic>\n                      mRNA expression levels were not significantly different (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.12,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.89 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.5, respectively) in the FHL group compared with the control group.\n                      <jats:italic toggle=\"yes\">SREBF1<\/jats:italic>\n                      gene expression was downregulated around 10-fold in the FHL group vs the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      The downregulation of\n                      <jats:italic toggle=\"yes\">SREBF1<\/jats:italic>\n                      in the liver tissue of cats with FHL does not support the hypothesis that de novo lipogenesis in the liver is an important pathway of fatty acid accumulation in FHL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19857853","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T08:54:41Z","timestamp":1563526481000},"page":"500-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Gene expressions of de novo hepatic lipogenesis in feline hepatic lipidosis"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-8885","authenticated-orcid":false,"given":"Chiara","family":"Valtolina","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris H","family":"Robben","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E","family":"van Wolferen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedwig S","family":"Kruitwagen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J","family":"Corbee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P","family":"Favier","sequence":"additional","affiliation":[{"name":"Evidensia Netherlands, Vleuten, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis C","family":"Penning","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The 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