{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:04Z","timestamp":1792787764596,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Langford Vets Clinical Research Grant","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Feline infectious peritonitis (FIP) is a high mortality infectious disease. Single nucleotide polymorphisms (SNPs) in the genes encoding interferon gamma (\n                      <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                      ), tumour necrosis factor alpha (\n                      <jats:italic toggle=\"yes\">TNFA<\/jats:italic>\n                      ) and dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin (DC-SIGN;\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      ) have been associated with increased and decreased risk of developing FIP. This study was designed to determine whether these associations were present in a UK population of pedigree cats using samples from cats euthanased with a confirmed diagnosis (FIP, n\u2009=\u200922; non-FIP, n\u2009=\u200910) or clinically healthy cats over 11 years of age (n\u2009=\u20093).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      DNA was extracted from tissue (n\u2009=\u200932) or blood (n\u2009=\u20093) and PCR performed for regions of\n                      <jats:italic toggle=\"yes\">IFNG, TNFA<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      . PCR amplicons were sequenced, each SNP genotype was determined, and genotype\/allele frequency for each SNP and FIP status were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant association was found between the genotype and FIP status for any SNP analysed. There was a trend for the heterozygous CT genotype at both\n                      <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                      g.401 and IFNG g.408 to be associated with FIP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.13), but this genotype was also found in a substantial proportion of non-FIP cats. There was also a trend for the heterozygous CT genotype at\n                      <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                      g.428 to be associated with FIP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.06), although most cats with FIP had the CC genotype at this locus. No associations were found between any allele at\n                      <jats:italic toggle=\"yes\">TNFA<\/jats:italic>\n                      g.-421,\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      g.1900,\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      g.2276,\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      g.2392 and\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      g.2713 and FIP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      The use of the\n                      <jats:italic toggle=\"yes\">IFNG, TNFA<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">CD209<\/jats:italic>\n                      SNPs described to predict the risk of FIP cannot currently be recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19865637","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:35:47Z","timestamp":1564738547000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of polymorphisms in inflammatory mediator and cellular adhesion genes as risk factors for feline infectious peritonitis"],"prefix":"10.1177","volume":"22","author":[{"given":"Helen","family":"Kedward-Dixon","sequence":"first","affiliation":[{"name":"The Roundhouse Veterinary Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-6662","authenticated-orcid":false,"given":"Emi N","family":"Barker","sequence":"additional","affiliation":[{"name":"Langford Vets, University of Bristol, Langford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Tasker","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School, University of Bristol, Langford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kipar","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Helps","sequence":"additional","affiliation":[{"name":"Langford Vets, University of Bristol, Langford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.15.419"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1995.56.04.429"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb13044.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.04.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1111"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12441875"},{"key":"e_1_3_3_8_2","first-page":"14","article-title":"The inheritance of susceptibility to feline infectious peritonitis in purebred catteries","volume":"24","author":"Foley JE","year":"1996","unstructured":"Foley JE, Pedersen NC. 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