{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:47:58Z","timestamp":1793119678200,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the relationship between the ultrasonographic (US) diffuse honeycomb pattern (HCP) of the spleen and a pathological diagnosis in cats, and to assess the influence of transducer type on HCP visualisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Abdominal ultrasounds of cats with an HCP were reviewed and splenic size, shape, margination, other parenchymal alterations and splenic hilar lymphadenopathy were recorded. When applicable, images acquired with high-frequency linear and curvilinear transducers were compared to determine if an HCP was more frequently demonstrated on high-resolution images. A retrospective review of the corresponding splenic cytohistopathological samples was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-three cats met the inclusion criteria. Five cases were diagnosed by histology and 28 by cytology, confirmed by PCR for antigen receptor rearrangements (PARR) in uncertain cases. There were 15 cases of lymphoid hyperplasia, eight cases of lymphoma (four B cell, three T cell and one large granular lymphocytes), six cats with splenitis, three with extramedullary haematopoiesis and one with histiocytic sarcoma. The prevalence of lymphoma in cats with an HCP of the spleen was 24%. Splenomegaly was the most frequent US feature associated with an HCP and was observed in all lymphoma cases. In the images obtained from both high-frequency linear and micro-convex transducers the visualisation of an HCP was enabled in all cases (24\/24) and in 62.5% (15\/24), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance:<\/jats:title>\n                    <jats:p>Based on our findings, a US HCP of the spleen in cats can be associated with benign and malignant disorders and is infrequently associated with lymphoma in comparison with dogs. Cytological or histological examination, possibly supplemented by PARR, should always be performed for diagnostic support. Use of high-frequency linear transducers is recommended to properly recognise an HCP or subtle changes in splenic parenchyma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x19873197","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T05:02:30Z","timestamp":1568955750000},"page":"800-804","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultrasonographic honeycomb pattern of the spleen in cats: correlation with pathological diagnosis in 33 cases"],"prefix":"10.1177","volume":"22","author":[{"given":"Manuela","family":"Quinci","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Bettini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-3920","authenticated-orcid":false,"given":"Alessia","family":"Diana","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4867-1.00010-6"},{"key":"e_1_3_2_3_2","first-page":"239","volume-title":"Atlas of small animal ultrasonography","author":"Hecht S","year":"2015","unstructured":"Hecht S, Mai W. Spleen. In: Penninck D, d\u2019Anjou MA (eds). Atlas of small animal ultrasonography. Ames, IA: John Wiley & Sons, 2015, pp 239\u2013258."},{"key":"e_1_3_2_4_2","first-page":"215","article-title":"Sonographically detectable splenic disorders in dogs with malignant lymphoma","volume":"43","author":"Eberhardt F","year":"2015","unstructured":"Eberhardt F, Kohler C, Krastel D, et al. Sonographically detectable splenic disorders in dogs with malignant lymphoma. Tierarztl Prax Ausg K Kleintiere Heimtiere 2015; 43: 215\u2013220.","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2894-6.00009-3"},{"key":"e_1_3_2_6_2","first-page":"679","volume-title":"Textbook of diagnostic radiology","author":"Larson MM","year":"2013","unstructured":"Larson MM. The liver and spleen. In: Thrall DE (ed). Textbook of diagnostic radiology. 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Practical physical concepts and artifacts. In: Penninck D, d\u2019Anjou MA (eds). Atlas of small animal ultrasonography. 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