{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:15Z","timestamp":1792597515518,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Polydactyly has been described in two breeds of domestic cats (Maine Coon and Pixie Bob) and in some outbred domestic cats (eg, Hemingway cats). In most cases, feline polydactyly is a non-syndromic preaxial polydactyly. Three variants located in a regulatory sequence involved in limb development, named ZRS (zone of polarising activity regulatory sequence), have been identified to be responsible for feline polydactyly. These variants have been found in outbred domestic cats in the UK (\n                      <jats:italic toggle=\"yes\">UK1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">UK2<\/jats:italic>\n                      variants) and in Hemingway cats in the USA (\n                      <jats:italic toggle=\"yes\">Hw<\/jats:italic>\n                      variant). The aim of this study was to characterise the genetic features of polydactyly in Maine Coon cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genotyping assay was used to identify the variant(s) segregating in a cohort of 75 polydactyl and non-polydactyl Maine Coon cats from different breeding lines from Europe, Canada and the USA. The authors performed a segregation analysis to identify the inheritance pattern of polydactyly in this cohort and analysed the population structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">Hw<\/jats:italic>\n                      allele was identified in a subset of polydactyl cats. Sequencing of two regulatory sequences involved in limb development did not reveal any other variant in polydactyl cats lacking the\n                      <jats:italic toggle=\"yes\">Hw<\/jats:italic>\n                      allele. Additionally, genotype\u2013phenotype and segregation analyses revealed the peculiar inheritance pattern of polydactyly in Maine Coon cats. The population structure analysis demonstrated a genetic distinction between\n                      <jats:italic toggle=\"yes\">Hw<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Hw<\/jats:italic>\n                      -free polydactyl cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Polydactyly in Maine Coon cats is inherited as an autosomal dominant trait with incomplete penetrance and variable expressivity, and this trait is characterised by genetic heterogeneity in the Maine Coon breed. Maine Coon breeders should be aware of this situation and adapt their breeding practices accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x20905061","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T07:04:48Z","timestamp":1582009488000},"page":"1103-1113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic heterogeneity of polydactyly in Maine Coon cats"],"prefix":"10.1177","volume":"22","author":[{"given":"Alexia","family":"Hamelin","sequence":"first","affiliation":[{"name":"National Veterinary School of Alfort, Maisons-Alfort, and Faculty of Medicine, University of Paris-Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Conchou","sequence":"additional","affiliation":[{"name":"Unit of Medical Imaging, National Veterinary School of Toulouse, University of Toulouse, Toulouse, 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Citres","sequence":"additional","affiliation":[{"name":"Antagene, La Tour de Salvagny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-8335","authenticated-orcid":false,"given":"Laurent","family":"Tiret","sequence":"additional","affiliation":[{"name":"National Veterinary School of Alfort, Maisons-Alfort, and Faculty of Medicine, University of Paris-Est, Cr\u00e9teil, France"},{"name":"U955 \u2013 IMRB, Team 10 \u2013 Biology of the Neuromuscular System, INSERM, UPEC, EFS, National Veterinary School of Alfort, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Gache","sequence":"additional","affiliation":[{"name":"NeuroMyoG\u00e8ne Institute, CNRS UMR5310, INSERM U1217, Faculty of Medicine, Rockefeller, Claude Bernard Lyon I University, Lyon, 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