{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:09Z","timestamp":1792597569036,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cats with hyperthyroidism have been reported to develop thromboembolism, with and without echocardiographic abnormalities consistent with hyperthyroidism. The objective of this study was to compare platelet function in cats with hyperthyroidism with euthyroid age-matched cats. We hypothesized that cats with hyperthyroidism have shortened collagen and adenosine diphosphate (C-ADP) closure times as measured with the platelet function analyzer (PFA-100) in comparison with healthy, age-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen hyperthyroid and nine euthyroid healthy cats &gt;7 years of age were recruited from the hospital population. Platelet function, measured using the C-ADP closure times by the PFA-100, and platelet count were measured in healthy euthyroid cats and cats with hyperthyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean\u2009\u00b1\u2009SD closure times were not significantly different between control (66.3\u2009\u00b1\u20099.6 s) and hyperthyroid cats (65.9\u2009\u00b1\u200911.5 s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.75). The mean\u2009\u00b1\u2009SD closure times of hyperthyroid cats that either were untreated or received methimazole for \u2a7d3 weeks (n\u2009=\u20096; mean 68.5\u2009\u00b1\u200915.4 s) was not different than that of cats treated for &gt;3 weeks (n\u2009=\u200910; mean 64.3\u2009\u00b1\u20098.9 s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.57). The mean automated platelet count was higher in the hyperthyroid group than in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Platelet function, as measured by closure time under high shear conditions using C-ADP as an agonist, was not affected by hyperthyroidism in this group of cats. Further research is needed to determine if a hypercoagulable state exists in hyperthyroid cats and the potential roles platelets and von Willebrand factor may have.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x20920585","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T08:50:36Z","timestamp":1590051036000},"page":"1214-1218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelet function in cats with hyperthyroidism"],"prefix":"10.1177","volume":"22","author":[{"given":"Elizabeth C","family":"Hiebert","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia\u2013Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-7789","authenticated-orcid":false,"given":"David L","family":"Panciera","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia\u2013Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M","family":"Boes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia\u2013Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Bartl","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia\u2013Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12249"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb01326.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1988.192.11.1546"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00062.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715584994"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2016.09.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16648182"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03993.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12573"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.577742"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-07-0496"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2644"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0801"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1994.55.05.619"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15331"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1988.tb00477.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1987.tb01982.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12325"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1995.tb00899.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1994.205.11.1550"},{"key":"e_1_3_2_22_2","first-page":"e44157","article-title":"Hemostasis in overt and subclinical hyperthyroidism.","volume":"15","author":"Ordookhani A","year":"2017","unstructured":"Ordookhani A, Burman KD. 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