{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:03:09Z","timestamp":1792008189216,"version":"4.4.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to establish the safety and efficacy of a novel multidrug lomustine-based chemotherapeutic protocol for cats with high-grade multicentric or mediastinal lymphoma, in an area endemic for feline leukemia virus (FeLV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included owned cats, diagnosed (cytologically) with multicentric or mediastinal lymphoma and treated with the LOPH (lomustine, vincristine [Oncovin; Antibi\u00f3ticos do Brasil], prednisolone and hydroxydaunorubicin [doxorubicin]) protocol. A complete blood count was performed before every chemotherapy session and any significant abnormalities recorded as possible related toxicities. Median survival time (MST) and disease-free interval were estimated by Kaplan\u2013Meier curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-one cats were included in this study. Nineteen (90.5%) tested positive for FeLV and were therefore considered to have persistent viremia. Complete response was reported in 81% (n\u2009=\u200917\/21), while three had partial remission and one had no response. Seven cats finished the induction protocol within 20\u201331 weeks (23.1\u2009\u00b1\u20094.5; median 20) and all seven received a maintenance protocol. The MST (lymphoma-related survival) for the 21 cats was 214 days. The MST was 214 days for cats with mediastinal lymphoma (n\u2009=\u200913), but it was not reached for multicentric lymphoma (n\u2009=\u20098;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.9). The MST of cats with persistent FeLV antigenemia was 171 days. Grade I anorexia and vomiting occurred in 19% of the cats (n\u2009=\u20094\/21). Hematologic toxicity was found in 100% of the cats at some point during their treatment, but it was mostly grade I or II. Neutropenia, thrombocytopenia and anemia occurred in 16\/21, 21\/21 and 15\/21 cats, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>The LOPH protocol was well tolerated by cats with lymphoma and persistent FeLV viremia, and resulted in a better MST than similar studies with other protocols. Novel studies and controlled trials are necessary in order to evaluate the efficacy of different protocols according to the lymphoma subtype, anatomic form and FeLV status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x20926893","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T04:36:05Z","timestamp":1595219765000},"page":"86-97","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["LOPH: a novel chemotherapeutic protocol for feline high-grade multicentric or mediastinal lymphoma, developed in an area endemic for feline leukemia virus"],"prefix":"10.1177","volume":"23","author":[{"given":"Rodrigo S","family":"Horta","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-7222","authenticated-orcid":false,"given":"Larissa M","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Vila Velha University, Vila Velha, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna V","family":"Sena","sequence":"additional","affiliation":[{"name":"Prof. Ricardo Alexandre Hippler Veterinary Hospital, Vila Velha University, Vila Velha, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella O","family":"Almeida","sequence":"additional","affiliation":[{"name":"Prof. Ricardo Alexandre Hippler Veterinary Hospital, Vila Velha University, Vila Velha, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2mara A","family":"Jaretta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Vila Velha University, Vila Velha, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela M","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Treevet, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archivaldo","family":"Reche J\u00fanior","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Zootechny, University of S\u00e3o Paulo (USP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0079"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/vco.12158","article-title":"Treatment of feline intermediate- to\u2009high-grade lymphoma with a modified University of Wisconsin\u2013Madison protocol: 119 cases (2004\u20132012)","volume":"14","author":"Collete AS","year":"2016","unstructured":"Collete AS, Allstadt SD, Chon EM, et al. Treatment of feline intermediate- to\u2009high-grade lymphoma with a modified University of Wisconsin\u2013Madison protocol: 119 cases (2004\u20132012). Vet Comp Oncol 2016; 14 Suppl 1: 136\u2013146.","journal-title":"Vet Comp Oncol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02703.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.3.371"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.05.021"},{"key":"e_1_3_2_7_2","first-page":"35","article-title":"Estudo cl\u00ednico da infec\u00e7\u00e3o de felinos pelo v\u00edrus da leucemia felina em S\u00e3o Paulo","volume":"4","author":"Hagiwara MK","year":"1997","unstructured":"Hagiwara MK, Reche AJr, Lucas SRR. Estudo cl\u00ednico da infec\u00e7\u00e3o de felinos pelo v\u00edrus da leucemia felina em S\u00e3o Paulo. Rev Bras Ci\u00eanc Vet 1997; 4: 35\u201338.","journal-title":"Rev Bras Ci\u00eanc Vet"},{"key":"e_1_3_2_8_2","first-page":"207","article-title":"Preval\u00eancia de leucemia felina em gatos dom\u00e9sticos de Uberl\u00e2ndia-MG","volume":"5","author":"Barbosa FC","year":"2001","unstructured":"Barbosa FC, Christianine MPT, Waldemarin KCA. Preval\u00eancia de leucemia felina em gatos dom\u00e9sticos de Uberl\u00e2ndia-MG. Arq Ci\u00eanc Vet Zool UNIPAR 2001; 5: 207\u2013211.","journal-title":"Arq Ci\u00eanc Vet Zool UNIPAR"},{"key":"e_1_3_2_9_2","first-page":"14","article-title":"Estudo epidemiol\u00f3gico de infec\u00e7\u00f5es pelo v\u00edrus da leucemia e\/ou imunodefici\u00eancia felina, em gatos dom\u00e9sticos do munic\u00edpio do Rio de Janeiro","volume":"36","author":"Souza JJM","year":"2002","unstructured":"Souza JJM, Teixeira CHR, Gra\u00e7a RFS. Estudo epidemiol\u00f3gico de infec\u00e7\u00f5es pelo v\u00edrus da leucemia e\/ou imunodefici\u00eancia felina, em gatos dom\u00e9sticos do munic\u00edpio do Rio de Janeiro. Clin Vet 2002; 36: 14\u201321.","journal-title":"Clin Vet"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(89)90132-3"},{"key":"e_1_3_2_11_2","first-page":"623","article-title":"Feline immunodeficiency virus and feline leukemia virus infections and their relationships to lymphoid malignancies in cats: a retrospective study (1968\u20131988)","volume":"3","author":"Shelton GH","year":"1990","unstructured":"Shelton GH, Grant CK, Cotter SM, et al. Feline immunodeficiency virus and feline leukemia virus infections and their relationships to lymphoid malignancies in cats: a retrospective study (1968\u20131988). J Acquir Immune Defic Syndr 1990; 3: 623\u2013630.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.03.056"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-5075"},{"key":"e_1_3_2_14_2","first-page":"166","article-title":"Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: II. Treatment of cats","volume":"19","author":"Cotter SM.","year":"1983","unstructured":"Cotter SM. Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: II. Treatment of cats. J Am Anim Hosp Assoc 1983; 19: 166\u2013172.","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13516621"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.0031.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1987.190.02.174"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01243.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12082"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02083.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1118"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2460\/javma.1989.194.05.696","article-title":"Treatment and prognostic factors in lymhpoma in cats: 103 cases (1977\u20131981)","volume":"194","author":"Mooney SC","year":"1989","unstructured":"Mooney SC, Hayes AA, MacEwen EG, et al. Treatment and prognostic factors in lymhpoma in cats: 103 cases (1977\u20131981). J Am Vet Med Assoc 1989; 194: 696\u2013702.","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12243"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0057.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02352.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02134.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.07.003"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00329.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12448017"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1678-4456.bjvras.2010.26848"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610215"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/30.3.194"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.283"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1939-1676.2006.tb00756.x","article-title":"Response of canine cutaneous epitheliotropic lymhpoma to lomustine (CCNU): a retrospective study of 46 cases (1999\u20132004)","volume":"20","author":"Ribson RE","year":"2006","unstructured":"Ribson RE, de Lorimier LP, Skorupski K, et al. Response of canine cutaneous epitheliotropic lymhpoma to lomustine (CCNU): a retrospective study of 46 cases (1999\u20132004). J Vet Intern Med 2006; 20: 1389\u20131397.","journal-title":"J Vet Intern Med"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02833.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12318"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.237"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12453836"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000162"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283425f44"},{"key":"e_1_3_2_41_2","first-page":"76","article-title":"Chemotherapy for lymphoma","volume":"4","author":"Crystal MA","year":"2011","unstructured":"Crystal MA, Schmidt BR. Chemotherapy for lymphoma. Feline Patient 2011; 4: 76\u201380.","journal-title":"Feline Patient"},{"key":"e_1_3_2_42_2","first-page":"667","volume-title":"Cancer in dogs and cats: medical and surgical management","author":"Vonderhaar MA","year":"1998","unstructured":"Vonderhaar MA, Morrison WB. Lymphosarcoma. In: Morrison WB (ed). Cancer in dogs and cats: medical and surgical management. Baltimore, MD: Williams & Wilkins, 1998, pp 667\u2013695."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0510-x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb02311.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12406"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.6.650"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12382"},{"key":"e_1_3_2_48_2","article-title":"Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy","volume":"12","author":"Skoetz N","year":"2015","unstructured":"Skoetz N, Bohlius J, Engert A, et al. Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy. Cochrane Database Syst Rev 2015; 12: CD007107. DOI: 10.1002\/14651858.CD007107.pub3.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6411"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.05.021"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.02.004"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00201.x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16666119"}],"updated-by":[{"DOI":"10.1177\/1098612x20957530","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000}}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X20926893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X20926893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X20926893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:52:46Z","timestamp":1784094766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X20926893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/1098612X20926893"],"URL":"https:\/\/doi.org\/10.1177\/1098612x20926893","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]}}}