{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:41:17Z","timestamp":1793814077790,"version":"4.6.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NCSU Feline Health Research Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The goal of this study was to document the outcomes and toxicity of a novel multimodality treatment protocol for feline gastrointestinal intermediate- or large-cell lymphoma (FGL) in which cats were treated at 21-day intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective, single-arm study. Twelve client-owned cats with cytologically diagnosed FGL were treated with a combination of abdominal cavity radiation therapy (RT; 8\u2009Gy total dose administered in two 4\u2009Gy fractions, 21 days apart), lomustine chemotherapy (approximately 40\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , administered orally at 21-day intervals for four treatments), prednisolone (5\u2009mg PO q24h) and cobalamin (250\u2009\u00b5g\/week SC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three cats were euthanized prior to the second treatment and it was difficult to discern treatment-associated toxicity from progressive disease. Four of the remaining cats developed cytopenias, resulting in 7\u201314-day lomustine treatment delays and\/or dose reductions. Six cats had a partial response to treatment and three had stable disease based on ultrasound at day 21 (50% overall response rate). Three of these six cats completed the study and lived &gt;240 days; one died of refractory diabetes mellitus with no clinical evidence of FGL, and the other two died as a result of FGL. The median overall survival time was 101 days (95% confidence interval [CI] 9\u2013240). The median progression-free survival time was 77 days (95% CI 8\u2013212). Necropsies were performed in eight cats, which revealed multifocal lymphoma throughout the gastrointestinal tract and other organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Oncological outcomes reported herein are comparable to those achieved with multiagent injectable chemotherapy (eg, CHOP). Treatment was seemingly well tolerated in most cats and was relatively cost-effective. It is therefore plausible that improved disease control may be achievable through continued optimization and intensification of the combinatorial chemoradiotherapy protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x20959602","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T10:09:29Z","timestamp":1601460569000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of feline gastrointestinal intermediate- or large-cell lymphoma with lomustine chemotherapy and 8 Gy abdominal cavity radiation therapy"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-4560","authenticated-orcid":false,"given":"Tracy L","family":"Gieger","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"},{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela S","family":"Seiler","sequence":"additional","affiliation":[{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA"},{"name":"Department of Molecular and Biological Sciences, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"},{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA"},{"name":"Duke Cancer Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2011.02.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.3.405"},{"key":"e_1_3_3_4_2","first-page":"69","article-title":"Feline gastrointestinal lymphoma: 67 cases.","volume":"4","author":"Fondocaro JV","year":"1999","unstructured":"Fondocaro JV, Richter KP, Carpenter JL, et al. 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