{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:44:18Z","timestamp":1790948658086,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Student Training in Advanced Research"},{"name":"Bailey Wrigley Fund"},{"DOI":"10.13039\/100005595","name":"university of california","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to determine famciclovir content (strength) in compounded formulations and to determine if potency changed over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four concentrations of oral oil suspension in three distinct flavors, three concentrations of oral paste, three chew treats and 62.5\u2009mg tablets from one compounding pharmacy were evaluated for famciclovir content. Specific sample preparation\u2009procedures were used for each\u2009drug formulation prior to determination of famciclovir content through mass spectrometry tandem liquid chromatography. Analysis was performed on arrival from the compounder and on days 7, 14, 28, 56 and 120. Samples were run in triplicate and concentration determined by comparison with a standard curve. Content was considered appropriate if within 90\u2013110% of the labeled concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On arrival from the compounding pharmacy, 5\/12 oral oil suspensions of varying concentrations were &lt;90% of the labeled concentration and 3\/3 oral pastes were &gt;110%. Famciclovir content in oil suspensions ranged from 72% to 118% of the label value while oral pastes ranged from 95% to 202% of the label concentration over the 120 study days, and all concentrations varied in an unpredictable fashion. Tablets contained 90\u2013110% of the labeled value throughout the study period. Chew treats could not be successfully analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>This study found substantial variation in famciclovir content in the compounded products evaluated, which, in turn, raises concerns that substandard dosing could result in lack of efficacy or a failed treatment trial. Drug toxicity might also be encountered. Veterinarians must be aware that while compounded medications can improve compliance, they might not deliver the drug dose expected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x20961046","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T04:41:12Z","timestamp":1601959272000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Drug content on receipt and over time for compounded formulations of famciclovir"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-5626","authenticated-orcid":false,"given":"Lynelle R","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe G","family":"Weaver","sequence":"additional","affiliation":[{"name":"William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E","family":"Forsythe","sequence":"additional","affiliation":[{"name":"University of Illinois Veterinary Teaching Hospital, Urbana, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M","family":"Thomasy","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA"},{"name":"Department of Ophthalmology &amp; Vision Science, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K","family":"Knych","sequence":"additional","affiliation":[{"name":"KL Maddy Equine Analytical Chemistry Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"44","article-title":"The diagnosis of ocular feline herpesvirus infection.","volume":"7","author":"Nasisse MP","year":"1997","unstructured":"Nasisse MP, Weigler BJ. 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