{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:28Z","timestamp":1792590388838,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate whether any admission vitals correlated with the presence of brain herniation diagnosed via MRI in cats presenting with neurologic signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records at two veterinary university referral centers were reviewed to identify cats that underwent brain MRI between 2010 and 2019. A control group of cats with intracranial lesions without concurrent brain herniation was analyzed for comparison. Data relating to signalment, vitals on admission, abnormalities observed on initial neurologic examination, underlying etiology, advanced imaging findings and outcome were reviewed. A Modified Glasgow Coma Scale (MGCS) score was determined retrospectively based on initial neurologic examination. Logistic regressions were performed to investigate the relationship between each risk factor and the odds of brain herniation as diagnosed on MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-two cats with brain herniation and 44 cats with abnormal brain MRI without evidence of herniation (as a control group) based on MRI findings were included. Cats with intracranial neoplasia vs other diagnoses were found to be at increased risk of herniation (odds ratio [OR] 4.8, 95% confidence interval [CI] 1.8\u201313.8;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). The odds of herniation increased with age (OR 1.1, 95% CI 1.01\u20131.2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031). Cats with herniation had a significantly lower level of consciousness in their MGCS score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001) than cats without herniation. There was no significant difference in either motor activity or brainstem reflexes between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Admission heart rate and blood pressure were not associated with brain herniation. Cats with herniation were presented with a significantly lower level of consciousness in their MGCS score; however, this clinical feature cannot be directly attributable to and predictive of herniation. Older cats with intracranial neoplasia are more likely to have brain herniation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x211048639","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T13:28:55Z","timestamp":1633699735000},"page":"770-778","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between admission vitals and brain herniation in 32 cats: a retrospective study"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-591X","authenticated-orcid":false,"given":"Jiwoong","family":"Her","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Merbl","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gerken","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Hofmeister","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore M","family":"Bacek","sequence":"additional","affiliation":[{"name":"BluePearl Veterinary Partners, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendon W","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-5032","authenticated-orcid":false,"given":"Amy B","family":"Yanke","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0168-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14526"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02525.x"},{"key":"e_1_3_3_5_2","unstructured":"Dewey CW. Practical guide to canine and feline neurology. 3rd ed. Chichester: Wiley-Blackwell 2016."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304042.05557.60"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2020-209635"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50102-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000245582.08532.7C"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-016-0341-1"},{"key":"e_1_3_3_12_2","article-title":"Relationship between admission variables in dogs with brain herniation: a retrospective study in 54 dogs [abstract].","volume":"34","author":"Her J","year":"2020","unstructured":"Her J, Yanke A, Jin Y, et al. Relationship between admission variables in dogs with brain herniation: a retrospective study in 54 dogs [abstract]. J Vet Intern Med 2020; 34: 2861.","journal-title":"J Vet Intern Med"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12885"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1975.tb05824.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00862.x"},{"key":"e_1_3_3_16_2","first-page":"174","article-title":"Cushing reflex associated with a presumed global brainstem ischemia in a dog: diagnostic procedures and outcome.","volume":"163","author":"Colson A","year":"2012","unstructured":"Colson A, Fanuel-Barret D, Jossier R, et al. Cushing reflex associated with a presumed global brainstem ischemia in a dog: diagnostic procedures and outcome. Rev Med Vet (Toulouse) 2012; 163: 174\u2013177.","journal-title":"Rev Med Vet (Toulouse)"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480270038006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16676022"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20-0111"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0530-x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei121"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1928.85.3.498"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020781"},{"key":"e_1_3_3_24_2","first-page":"1156","article-title":"Brain herniation in 113 cats: a descriptive study [abstract].","volume":"29","author":"Freitas MI","year":"2015","unstructured":"Freitas MI, De, Leibel F, Goncalves R, et al. Brain herniation in 113 cats: a descriptive study [abstract]. J Vet Intern Med 2015; 29: 1156\u20131157.","journal-title":"J Vet Intern Med"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.614026"},{"key":"e_1_3_3_26_2","first-page":"2405","volume-title":"Textbook of small animal surgery","author":"Oakley R","year":"2003","unstructured":"Oakley R, Patterson J. Tumors of the central and peripheral nervous system. In: Slatter D (ed). Textbook of small animal surgery. Philadelphia, PA: Elsevier Science, 2003, pp 2405\u20132425."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1994.tb00452.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.1.JNS152385"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01594.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12368"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15802"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12398"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12677"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14900"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X211048639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X211048639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X211048639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:20:21Z","timestamp":1792588821000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X211048639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/1098612X211048639"],"URL":"https:\/\/doi.org\/10.1177\/1098612x211048639","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]}}}