{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:23Z","timestamp":1792590383297,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018065","name":"EveryCat Health Foundation","doi-asserted-by":"publisher","award":["MT19-006"],"award-info":[{"award-number":["MT19-006"]}],"id":[{"id":"10.13039\/100018065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to characterize gastrointestinal (GI) transit times and pH in healthy cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GI transit times and pH were measured in six healthy, colony-housed, purpose-bred spayed female cats using a continuous, non-invasive pH monitoring system in a sequential order design. For the first period (\u2018pre-feeding\u2019), food was withheld for 20\u2009h, followed by oral administration of a pH capsule. Five hours post-capsule administration, cats were meal-fed by offering them their daily allowance of food for 1\u2009h. For the second period (\u2018post-feeding\u2019), food was withheld for 24\u2009h and cats were fed for 1\u2009h, after which a pH capsule was orally administered. Studies in both periods were repeated three times. GI transit times and pH were compared between the two periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median transit times for the pre- and post-feeding periods, respectively, were: gastric \u2013 94\u2009mins (range 1\u20134101) and 1068 mins (range 484\u20135521); intestinal \u2013 1350\u2009mins (range 929\u20132961) and 1534\u2009mins (range 442\u20132538); and GI \u2013 1732\u2009mins (range 1105\u20135451) and 2795\u2009mins (range 926\u20136563). The median GI pH values for the first and second periods, respectively, were: esophageal \u2013 7.0 (range 3.5\u20137.8) and 4.5 (range 2.9\u20136.4); gastric \u2013 2.7 (range 1.7\u20136.2) and 2.0 (range 1.1\u20133.3); intestinal \u2013 8.2 (range 7.6\u20138.7) and 7.8 (range 6.7\u20138.5); first-hour small intestinal \u2013 8.2 (range 7.4\u20138.7) and 8.3 (range 7.9\u20138.6); and last-hour large intestinal \u2013 8.5 (range 7.0\u20138.9) and 7.8 (range 6.3\u20138.7). Gastric (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0020) and intestinal pH (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0059) were significantly increased in the pre-feeding period compared with the post-feeding period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Gastric and intestinal pH differed significantly when the capsule was administered 5\u2009h prior to feeding compared with 1\u2009h after feeding. Transit times for both periods showed high degrees of intra- and inter-individual variability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x211062096","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T09:56:52Z","timestamp":1638957412000},"page":"954-961","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of gastrointestinal transit times and pH in healthy cats using a continuous pH monitoring system"],"prefix":"10.1177","volume":"24","author":[{"given":"Naila J","family":"Telles","sequence":"first","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M","family":"Scallan","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily N","family":"Gould","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G","family":"Papich","sequence":"additional","affiliation":[{"name":"North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"He","sequence":"additional","affiliation":[{"name":"North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Tien","family":"Lee","sequence":"additional","affiliation":[{"name":"North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Lidbury","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg M","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Kathrani","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-9530","authenticated-orcid":false,"given":"M","family":"Katherine Tolbert","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15430"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12493"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12580"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15887"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12670"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.2.195"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03481.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23159"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14807"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.08.005"},{"key":"e_1_3_3_12_2","unstructured":"US Food and Drug Administration. 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