{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:18Z","timestamp":1792590378237,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to collect clinical information from owners of cats with hypersomatotropism (HS) distributed worldwide, assessing the impact of HS and its treatments on cats\u2019 quality of life (QoL) and survival time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey focused on clinical presentation, diagnostic procedures, treatments, cats\u2019 QoL and disease progression was distributed worldwide to owners of cats with HS. The owner\u2019s perception of the cats\u2019 QoL before and after or during treatment was defined using a score ranging from 1 (poor) to 5 (excellent). Improvement following treatment (IFT) was quantified using a score ranging from 1 (absent) to 5 (obvious). Different treatment groups, including at least five cases, were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 127 cats were included from at least 11 different countries. Among these, 120 (95%) were diabetic and 7 (5%) were not. Out of 120 diabetic cats, 55 (46%) were treated with insulin as a single treatment (INS). Other treatments were not mentioned to owners in 35\/120 (29%) cases. The median QoL score at diagnosis was 2 (range 1\u20135) and improved after treatment in all groups. Cabergoline (4; range 1\u20135), radiotherapy (4; range 2\u20135) and hypophysectomy (5; range 4\u20135) showed better median IFT scores compared with INS (3; range 1\u20135) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.046,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.002 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001, respectively). Hypophysectomy IFT proved superior to cabergoline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.047) and was equal to radiotherapy IFT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.32). No difference was found between cabergoline and radiotherapy IFT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.99). The median survival time (MST) was 24 months (range 0\u201375 months). Cats treated with INS showed shorter MST (22 months; range 0\u201369 months) compared with cats treated with causal treatments combined (36 months; range 3\u201375 months) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Not all cats with HS will have diabetes mellitus. Causal treatments seem associated with the greatest improvements in perceived cats\u2019 QoL and survival; such treatments should therefore be discussed with owners. Cabergoline could be an effective alternative management option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221098718","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T05:09:27Z","timestamp":1653541767000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Quality of life and response to treatment in cats with hypersomatotropism: the owners\u2019 point of view"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-8715","authenticated-orcid":false,"given":"Andrea","family":"Corsini","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell\u2019Emilia, Italy"},{"name":"Department of Veterinary Medical Sciences, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn JM","family":"Niessen","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, London, UK"},{"name":"Veterinary Specialist Consultations, Hilversum, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-2741","authenticated-orcid":false,"given":"Diego D","family":"Miceli","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Buenos Aires, CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Caney","sequence":"additional","affiliation":[{"name":"Vet Professionals, Midlothian Innovation Centre, Roslin, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian K","family":"Zeugswetter","sequence":"additional","affiliation":[{"name":"Clinical Department for Small Animals and Horses, Veterinarmedizinische Universitat Wien, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja S","family":"Sieber-Ruckstuhl","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-7689","authenticated-orcid":false,"given":"Carolina","family":"Arenas","sequence":"additional","affiliation":[{"name":"AniCura Hospital Veterinario Valencia Sur, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M","family":"Fleeman","sequence":"additional","affiliation":[{"name":"Animal Diabetes Australia, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-4062","authenticated-orcid":false,"given":"Rodolfo O","family":"Leal","sequence":"additional","affiliation":[{"name":"CIISA \u2013 Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Battellino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell\u2019Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-2199","authenticated-orcid":false,"given":"Federico","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell\u2019Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00226"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.12.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.12.004"},{"key":"e_1_3_3_5_2","article-title":"Sciatic neuropathy in an acromegalic cat without concurrent diabetes mellitus.","volume":"6","author":"Corsini A","year":"2020","unstructured":"Corsini A, Bianchi E, Volta A, et al. Sciatic neuropathy in an acromegalic cat without concurrent diabetes mellitus. JFMS Open Rep 2020; 6. DOI: 10.1177\/2055116920906936.","journal-title":"JFMS Open Rep"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127794"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16664390"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14360"},{"key":"e_1_3_3_9_2","article-title":"Acromegaly in a non-diabetic cat.","volume":"2","author":"Fracassi F","year":"2016","unstructured":"Fracassi F, Salsi M, Sammartano F, et al. Acromegaly in a non-diabetic cat. JFMS Open Rep 2016; 2. DOI: 10.1177\/2055116916646585.","journal-title":"JFMS Open Rep"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16080"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16047"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0242.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15212"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12608"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14662"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20933213"},{"key":"e_1_3_3_17_2","article-title":"Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment.","volume":"7","author":"Miceli DD","year":"2021","unstructured":"Miceli DD, Vidal PN, Pompili GA, et al. Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment. JFMS Open Rep 2021; 7. DOI: 10.1177\/20551169211018991.","journal-title":"JFMS Open Rep"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194342"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03041.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.7.886"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03040.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221074924"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221098718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X221098718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221098718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:19:44Z","timestamp":1792588784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X221098718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/1098612X221098718"],"URL":"https:\/\/doi.org\/10.1177\/1098612x221098718","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}