{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:25:53Z","timestamp":1793255153523,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Although radioiodine (\n                      <jats:sup>131<\/jats:sup>\n                      I) is the treatment of choice for feline hyperthyroidism,\n                      <jats:sup>131<\/jats:sup>\n                      I-dosing protocols commonly induce iatrogenic hypothyroidism and expose azotaemia. A recently reported patient-specific\n                      <jats:sup>131<\/jats:sup>\n                      I dosing algorithm minimised the risk of\n                      <jats:sup>131<\/jats:sup>\n                      I-induced hypothyroidism and azotaemia, while maintaining high cure rates. The aim of the study was to report results of\n                      <jats:sup>131<\/jats:sup>\n                      I treatment in a European population of hyperthyroid cats using this patient-specific dosing algorithm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective case series (before-and-after study) evaluated 165 hyperthyroid cats referred for\n                      <jats:sup>131<\/jats:sup>\n                      I treatment. All cats had serum concentrations of thyroxine (T4), triiodothyronine (T3) and thyroid-stimulating hormone (TSH) measured (off methimazole \u2a7e1 week). Thyroid volume and percentage uptake of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-pertechnetate (TcTU) were determined using thyroid scintigraphy. An initial\n                      <jats:sup>131<\/jats:sup>\n                      I dose was calculated by averaging dose scores for T4\/T3 concentrations, thyroid volume and TcTU; 70% of that composite dose was then administered. Twenty-four hours later, percentage\n                      <jats:sup>131<\/jats:sup>\n                      I uptake was measured, and additional\n                      <jats:sup>131<\/jats:sup>\n                      I administered as needed to deliver an adequate radiation dose to the thyroid tumour(s). Serum concentrations of T4, TSH and creatinine were determined 6\u201312 months later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median calculated\n                      <jats:sup>131<\/jats:sup>\n                      I dose was 2.15 mCi (range 1.2\u20137.5), with only 51 (30.9%) receiving \u2a7e2.5\u2009mCi. Of 165 cats, 124 (75.2%) became euthyroid, seven (4.2%) became overtly hypothyroid, 27 (16.4%) became subclinically hypothyroid and seven (4.2%) remained hyperthyroid. A higher proportion of overtly (85.7%) and subclinically (26.9%) hypothyroid cats developed azotaemia than euthyroid cats (13.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0002). Hypothyroid cats were older (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.016) and more likely to have detectable TSH concentrations (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.025) and symmetrical bilateral distribution of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-pertechnetate uptake (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0002), whereas persistently hyperthyroid cats had higher severity scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      Our results confirm that\n                      <jats:sup>131<\/jats:sup>\n                      I dosing with this new algorithm results in high cure rates, with a lowered prevalence of\n                      <jats:sup>131<\/jats:sup>\n                      I-induced overt hypothyroidism and azotaemia. Age, serum TSH concentrations, bilateral, symmetrical uptake and severity score help predict outcome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221104743","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:12:50Z","timestamp":1656065570000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Radioiodine treatment of hyperthyroidism in cats: results of 165 cats treated by an individualised dosing algorithm in Spain"],"prefix":"10.1177","volume":"24","author":[{"given":"Pilar","family":"Xifra","sequence":"first","affiliation":[{"name":"IODOCAT, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara I","family":"Serrano","sequence":"additional","affiliation":[{"name":"IODOCAT, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-1855","authenticated-orcid":false,"given":"Mark E","family":"Peterson","sequence":"additional","affiliation":[{"name":"Animal Endocrine Clinic, New York, NY, USA"},{"name":"Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.21.711"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14646"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15296"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18822396"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13057"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.1671"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0566.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0550.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12695"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15036"},{"key":"e_1_3_3_12_2","first-page":"156","volume-title":"Feline endocrinology","author":"Williams T","year":"2019","unstructured":"Williams T. Thyroid and kidney disease in cats. In: Feldman EC, Fracassi F, Peterson ME (eds). Feline endocrinology. Milan: EDRA, 2019, pp 156\u2013168."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16228"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16319"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jaba.691"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13585"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17708918"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13500426"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12165"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12360"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15572416"},{"key":"e_1_3_3_22_2","first-page":"169","volume-title":"Feline endocrinology","author":"Broome MR","year":"2019","unstructured":"Broome MR, et al Thyroid imaging. In: Feldman EC, Fracassi F, Peterson ME (eds). Feline endocrinology. Milan: EDRA, 2019, pp 169\u2013197."},{"key":"e_1_3_3_23_2","first-page":"267","volume-title":"Feline endocrinology","author":"Broome MR","year":"2019","unstructured":"Broome MR, et al. Treatment of hyperthyroidism: severe, unresponsive, or recurrent hyperthyroidism. In: Feldman EC, Fracassi F, Peterson ME (eds). Feline endocrinology. Milan: EDRA, 2019, pp 267\u2013280."},{"key":"e_1_3_3_24_2","first-page":"227","volume-title":"Feline endocrinology","author":"Peterson ME","year":"2019","unstructured":"Peterson ME, et al. Treatment of hyperthyroidism: radioiodine. In: Feldman EC, Fracassi F, Peterson ME (eds). Feline endocrinology. Milan: EDRA, 2019, pp 227\u2013254."},{"key":"e_1_3_3_25_2","first-page":"281","volume-title":"Feline endocrinology","author":"Peterson ME","year":"2019","unstructured":"Peterson ME. Hypothyroidism. In: Feldman EC, Fracassi F, Peterson ME (eds). Feline endocrinology. Milan: EDRA, 2019, pp 281\u2013316."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2008.10.001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15575385"},{"key":"e_1_3_3_28_2","first-page":"367","volume-title":"Goodness-of-fit techniques","author":"D\u2019Agostino RB","year":"1986","unstructured":"D\u2019Agostino RB. Tests for normal distribution. In: D\u2019Agostino RB, Stephens MA (eds). Goodness-of-fit techniques. New York: Macel Dekker, 1986, pp 367\u2013420."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90791-0"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.2.g99mr30481"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.03.005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.1242"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0403"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221104743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X221104743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221104743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:20:29Z","timestamp":1792588829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X221104743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/1098612X221104743"],"URL":"https:\/\/doi.org\/10.1177\/1098612x221104743","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]}}}