{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:19Z","timestamp":1792590379720,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The most common use of plasma transfusion is for haemostatic purposes, but coagulation factor activities in stored feline plasma are unknown. The concentration and stability of coagulation factors I (fibrinogen), II, V, VII, VIII, IX, X, XI and XII in feline fresh frozen plasma (fFFP) stored for 1 year were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-five units of fFFP were produced from 55 fresh whole-blood donations obtained from indoor healthy blood donor cats. Twenty-one units were stored for &lt;2 weeks (T0) and 34 were stored for 1 year (T1). After the completion of storage, specific coagulation factor activities for factors II, V, VII, VIII, IX, X, XI and XII were tested using modified one-stage activated partial thromboplastin or prothrombin time assays. Fibrinogen was determined using the Clauss method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly decreased activities were observed for factors II (T0: 101.94%\u2009\u00b1\u200919.06%; T1: 73.23%\u2009\u00b1\u200939.06% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001]), VII (T0: 102.78%\u2009\u00b1\u200924.69%; T1: 60.08%\u2009\u00b1\u200938.17% [\n                      <jats:italic toggle=\"yes\">P &lt;0.001<\/jats:italic>\n                      ]), VIII (T0: 77.52%\u2009\u00b1\u200930.39%; T1: 50.32%\u2009\u00b1\u200923.8% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001]), XI (T0: 88.76%\u2009\u00b1\u200922.73%; T1: 66.28%\u2009\u00b1\u200922.2% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001]) and XII (T0: 89.50%\u2009\u00b1\u200921.85%; T1: 55.46%\u2009\u00b1\u200923.18% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001]) when comparing units at time 0 and after 1 year of storage. No significant difference was observed for factors IX (T0: 84.86%\u2009\u00b1\u200929.35%; T1: 71.37%\u2009\u00b1\u200922.23% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.064]) and X (T0: 96.24%\u2009\u00b1\u200925.1%; T1: 83.91%\u2009\u00b1\u200949.54% [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.236]). Unexpectedly, a significant increase was observed for factor V (T0: 71.94%\u2009\u00b1\u200924.14%; T1: 97.89%\u2009\u00b1\u200962.33%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.046). Fibrinogen was 2.76\u2009\u00b1\u20091.09\u2009g\/l at T1. Factors VIII, XII and VII had the lowest mean activities after 1 year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Although a decrease in most coagulation factors activities was noted with storage, 1-year-old fFFP was haemostatically active in vitro. The most suitable factors for quality control assessment of fFFP are factors VII and VIII. Approximately 13\u201320\u2009ml\/kg of fFFP is required to administer a minimum of 10\u2009IU\/kg coagulation factor activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221114630","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T10:06:46Z","timestamp":1662026806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Stability of coagulation factors in feline fresh frozen plasma intended for transfusion after 1 year of storage"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-2016","authenticated-orcid":false,"given":"Carles","family":"Blasi-Brugu\u00e9","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery, Veterinary Faculty, Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui RF","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Animal Blood Bank, Barcelona, Spain"},{"name":"Animal Blood Bank, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio M","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Animal Blood Bank, Barcelona, Spain"},{"name":"Department of Internal Medicine, Hospital A\u00fana Veterinary Specialties, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto JF","family":"de Matos","sequence":"additional","affiliation":[{"name":"Animal Science and Study Centre, Food and Agrarian Sciences and Technologies Institute, University of Porto, Porto, Portugal"},{"name":"Department of Veterinary Clinics, Institute for Biomedical Sciences of Abel Salazar, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ruiz de Gopegui","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Veterinary Faculty, Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1365840"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781118933053.ch4"},{"key":"e_1_3_3_4_2","first-page":"744","author":"Brooks M.","year":"2010","unstructured":"Brooks M. Transfusion of plasma products. In: Weiss DJ, Wardrop KJ (eds). Schalm\u2019s veterinary hematology. 6th ed. Ames, IA: Wiley-Blackwell, 2010, pp 744\u2013750.","journal-title":"Schalm\u2019s veterinary hematology"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12972"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2001.tb00264.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1458-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000465316"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12097"},{"key":"e_1_3_3_10_2","first-page":"822","author":"Blois S.","year":"2016","unstructured":"Blois S. Hyper- and hypocoagulable states. In: Ettinger SJ, Feldman EC, Cote E (eds). Textbook of veterinary internal medicine. 8th ed. St Louis, MO: Elsevier, 2016, pp 822\u2013829.","journal-title":"Textbook of veterinary internal medicine"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-02-0123"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-8-199904200-00004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-292094"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15872"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.04.053"},{"key":"e_1_3_3_16_2","first-page":"377","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Committee (partial agreement) on Blood Transfusion","year":"2017","unstructured":"European Committee (partial agreement) on Blood Transfusion. Plasma components. In: Keitel S (ed). Guide to the preparation, use and quality assurance of blood components. 19th ed. Strasbourg: EDQM, 2017, pp 377\u2013398.","edition":"19"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15167"},{"key":"e_1_3_3_18_2","first-page":"50","article-title":"Quality control of frozen plasma in 8 blood transfusion centers in the Croatian Republic [article in Croatian].","volume":"114","author":"Grgicevi\u0107 D","year":"1992","unstructured":"Grgicevi\u0107 D, Giudici E, Horvat J, et al. Quality control of frozen plasma in 8 blood transfusion centers in the Croatian Republic [article in Croatian]. Lijec Vjesn 1992; 114: 50\u201352.","journal-title":"Lijec Vjesn"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_97_17"},{"key":"e_1_3_3_20_2","first-page":"161","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"European Committee (partial agreement) on Blood Transfusion","year":"2017","unstructured":"European Committee (partial agreement) on Blood Transfusion. Principles of blood component processing. In: Keitel S (ed). Guide to the preparation, use and quality assurance of blood components. 19th ed. Strasbourg: EDQM, 2017, pp 161\u2013182.","edition":"19"},{"key":"e_1_3_3_21_2","first-page":"1005","article-title":"Estudo da estabilidade do plasma humano fresco congelado destinada a produ\u00e7\u00e3o de hemoderivados.","volume":"96","author":"Borba De Andrade S","year":"2015","unstructured":"Borba De Andrade S, Rolim LA, Neto PJR. Estudo da estabilidade do plasma humano fresco congelado destinada a produ\u00e7\u00e3o de hemoderivados. 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