{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:28Z","timestamp":1792590388281,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hyperthyroidism frequently affects middle-to-older-aged cats that can present with cardiorespiratory signs. The effects of hyperthyroidism on cardiac size and function have been previously documented. Anecdotally, pulmonary hyperinflation identified on thoracic radiographs may also be associated with hyperthyroidism; however, there is no literature to support this claim. The goal of this study was to determine any association between hyperthyroidism, pulmonary hyperinflation and cardiomegaly with the following hypotheses: (1) hyperthyroid cats would not have evidence of radiographic pulmonary hyperinflation compared with control cats; and (2) hyperthyroid cats were more likely to have evidence of radiographic cardiomegaly than control cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case-control study, the thoracic radiographs of 52 hyperthyroid cats and 46 non-hyperthyroid cats were evaluated for subjective and objective measurements of pulmonary hyperinflation and cardiomegaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no statistically significant differences between hyperthyroid and non-hyperthyroid cats for any variable indicative of pulmonary hyperinflation. The mean\u2009\u00b1\u2009SD vertebral heart score on lateral views for hyperthyroid cats was 7.75\u2009\u00b1\u20090.53 and for control cats was 7.55\u2009\u00b1\u20090.54, which was significantly different (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.05). Among all cats, a more severe total elevation in thyroxine (T4) was correlated with a larger vertebral heart score on lateral views (Spearman\u2019s correlation coefficient\u2009=\u20090.23,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>While the results of this study suggest that hyperthyroid cats are more likely to have a larger vertebral heart score on lateral views than control cats, the clinical relevance of this finding is unclear given the large degree of overlap between hyperthyroid and non-hyperthyroid cats. In addition, among all cats, a greater total T4 elevation was weakly correlated with a larger vertebral heart score. Hyperthyroidism is not associated with radiographic pulmonary hyperinflation and is an unlikely differential for this radiographic finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221118190","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T06:14:27Z","timestamp":1661926467000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between feline hyperthyroidism and thoracic radiographic evaluation of cardiomegaly and pulmonary hyperinflation"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-9502","authenticated-orcid":false,"given":"Victoria","family":"Young","sequence":"first","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B","family":"Shropshire","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J","family":"Marolf","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Veterinary internal medicine","author":"Mooney CT","year":"2010","unstructured":"Mooney CT. Feline hyperthyroidism. In: Ettinger SJ, Feldman EC (eds). Veterinary internal medicine. 7th ed. St Louis, MO: Elsevier Saunders, 2010.","edition":"7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16643252"},{"key":"e_1_3_2_4_2","first-page":"131","article-title":"Clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism.","volume":"47","author":"L\u00e9cuyer M","year":"2006","unstructured":"L\u00e9cuyer M, Prini S, Dunn ME, et al. Clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism. Can Vet J 2006; 47: 131\u2013135.","journal-title":"Can Vet J"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19900408"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.10.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18823348"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.3.367"},{"key":"e_1_3_2_9_2","first-page":"132","article-title":"Anaplastic tracheal squamous cell carcinoma in a cat.","volume":"63","author":"Lobetti RG","year":"1992","unstructured":"Lobetti RG, Williams MC. Anaplastic tracheal squamous cell carcinoma in a cat. J S Afr Vet Assoc 1992; 63: 132\u2013133.","journal-title":"J S Afr Vet Assoc"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1996.tb00810.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15745"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.05.011"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00099.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1988.192.11.1546"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-1-27"},{"key":"e_1_3_2_16_2","volume-title":"Textbook of veterinary diagnostic radiology","author":"Thrall DE","year":"2013","unstructured":"Thrall DE. The canine and feline lung. In: Textbook of veterinary diagnostic radiology. 6th ed. St Louis, MO: Elsevier Saunders, 2013.","edition":"6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.210"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14522048"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09122640"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0033"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2008.00655.x"},{"key":"e_1_3_2_22_2","first-page":"676","article-title":"Radiographic appearance of cardiogenic pulmonary edema in cats [abstract].","volume":"40","author":"McKlveen TL","year":"1999","unstructured":"McKlveen TL, Moon ML. Radiographic appearance of cardiogenic pulmonary edema in cats [abstract]. Vet Radiol Ultrasound 1999; 40: 676.","journal-title":"Vet Radiol Ultrasound"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221118190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X221118190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221118190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:20:19Z","timestamp":1792588819000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X221118190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1177\/1098612X221118190"],"URL":"https:\/\/doi.org\/10.1177\/1098612x221118190","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}