{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:47:27Z","timestamp":1792590447825,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In humans, renal aging is associated with an increased frequency of glomerulosclerosis, interstitial fibrosis, inflammation and tubular atrophy. The purpose of this study was to describe the frequency of renal histopathologic lesions in cats without kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study of archival kidney tissue from 74 cats without kidney disease (serum creatinine &lt;1.6\u2009mg\/dl; urine specific gravity &gt;1.035) was carried out: 0\u20134 years (young, n\u2009=\u200918); 5\u20139 years (mature, n\u2009=\u200916); 10\u201314 years (senior, n\u2009=\u200934), 15+\u2009years (geriatric, n\u2009=\u20096). Glomerulosclerosis, tubular atrophy, interstitial inflammation and fibrosis, and the presence or absence of lipid in the interstitium and tubules were scored by a pathologist masked to clinical data. Statistical analyses were performed as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Geriatric cats had significantly more glomerulosclerosis than mature (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01) and young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004). Senior cats had significantly more glomerulosclerosis than young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006). Glomerulosclerosis was weakly positively correlated with age (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.48;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001). Geriatric cats had significantly more tubular atrophy than mature (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02) and young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001). Senior cats had significantly more tubular atrophy than young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001). Geriatric cats had significantly more inflammation than senior cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02), mature cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01) and young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001). Senior cats had significantly more inflammation than young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004). Geriatric and senior cats had significantly more fibrosis than young cats (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04, respectively). Frequency of tubular lipid increased with age (young: 28%; mature: 56%; senior: 79%; geriatric: 100%) as did the frequency of interstitial lipid (young: 22%, mature: 56%, senior: 85%, geriatric: 100%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Evidence of renal aging exists in cats. These changes imply that the aging kidney may be more susceptible to injury and impaired healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221123768","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T08:11:42Z","timestamp":1670487102000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Frequency of histologic lesions in the kidneys of cats without kidney disease"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-0452","authenticated-orcid":false,"given":"Jessica M","family":"Quimby","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M","family":"McLeland","sequence":"additional","affiliation":[{"name":"International Veterinary Renal Pathology Service, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"International Veterinary Renal Pathology Service, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine F","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody P","family":"Lulich","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara B","family":"Barron","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists, Higham Gobion, Hitchin, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.02.036"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2015.08.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815612153"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.09-0443"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0110.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017040421"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00543.2007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02500.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150915358"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.05.002"},{"key":"e_1_3_3_13_2","first-page":"127","article-title":"Feline renal failure: questions, answers, questions.","volume":"14","author":"Lulich JP","year":"1992","unstructured":"Lulich JP, O'Brien TD, Osborne CA, et al. 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